Table 3.

Model-based ORs and 95% CIs for the association of CYP1B1/COMT expression in adjacent nontumor tissue with breast cancer risk

Expression levels*Reference pointsNumber
Model-based OR (95% CI)
BCBBD
CYP1B1
    <18.910.65140.21 (0.07-0.67)
    18.9-30.026.67130.81 (0.69-0.95)
    30.1-42.535.113131.00 (reference)
    42.6-66.448.520131.20 (1.05-1.38)
    >66.4100.718141.55 (1.12-2.15)
COMT
    <40.835.028131.72 (1.17-2.55)
    40.8-49.345.56131.19 (1.05-1.35)
    49.4-68.355.313131.00 (reference)
    68.4-86.478.74130.83 (0.73-0.95)
    >86.499.912130.78 (0.65-0.93)
  • * Gene expression levels were categorized by quintiles of CYP1B1 or COMT levels in BBD subjects.

  • The middle value in each quintile was assigned as the reference point.

  • Number of subjects for breast cancer and BBD.