Table 4.

Summary statistics (mean (Embedded Image) and SD) based on CSF set II by cigarette type for ILCR values for 13 carcinogens for z = 1 pack-year

ToxicantCASRNCSF set II (mg/kg-d)−1R
Lt
Ult
PREP
Embedded ImageSDEmbedded ImageSDEmbedded ImageSDEmbedded ImageSD
Acetaldehyde75-07-00.01*7e−058e−067e−058e−064e−051e−055e−065e−06
Acrylonitrile107-13-11.0*1e−043e−051e−043e−056e−053e−051e−051e−05
4-Aminobiphenyl92-67-121*5e−079e−084e−074e−082e−076e−082e−079e−08
Arsenic7440-38-212*8e−072e−076e−072e−073e−072e−072e−08NA
Benzene71-43-20.1*4e−055e−063e−054e−062e−058e−064e−064e−06
Benzo[a]pyrene50-32-83.9*5e−078e−084e−075e−082e−076e−084e−085e−08
1,3-Butadiene106-99-00.6*2e−044e−052e−044e−051e−044e−053e−053e−05
Cadmium7440-43-915*1e−052e−068e−061e−064e−062e−066e−075e−07
Formaldehyde50-00-00.021*7e−061e−065e−062e−062e−061e−061e−061e−06
Lead7439-92-10.042*1e−082e−091e−082e−095e−092e−093e−091e−10
NNK64091-91-449§4e−055e−063e−055e−062e−056e−064e−067e−07
N-Nitrosonornicotine80508-23-21.4*2e−063e−071e−063e−078e−073e−071e−076e−08
Quinoline91-22-532e−058e−061e−054e−067e−062e−062e−061e−06
Cancer risk subtotals
    Human lung carcinogens, Embedded Image1e−043e−051e−043e−057e−053e−051e−051e−05
    All cancers: Embedded Image5e−047e−055e−048e−053e−049e−054e−055e−05
  • NOTE: Conventional cigarettes classified by FTC tar yield as follows (30): regular, tar ≥ 15.0 mg; light, 6.0 mg ≤ tar < 15.0 mg; and ultralight, 1.0 ≤ tar < 6.0 mg. PREP cigarettes not characterized by tar content.

  • * Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. Sept. 2004 Cancer Potency List (46).

  • NA = not available: limited PREP yield data did not allow calculations for some chemicals. Each mean corresponds to a different number of PREPs because each PREP study measured different chemicals.

  • CSF was determined from an oral exposure study.

  • § CSF, 49 for all cancer end points. California Environmental Protection Agency. Sept. 2001 Expedited Cancer Potency Values and No Significant Risk Levels for Six Proposition 65 Carcinogens (47).

  • Integrated Risk Information System, U.S. Environmental Protection Agency (44).

  • Embedded Image = sum of Embedded Image for known human lung carcinogens considered here: acrylonitrile, arsenic, cadmium, and formaldehyde.