Table 3.

Summary statistics [mean (Embedded Image) and SD] based on CSF set I by cigarette type for ILCR values for 13 carcinogens for z = 1 pack-year

ToxicantCASRNCSF set I (mg/kg-d)−1R
Lt
ULt
PREP
Embedded ImageSDEmbedded ImageSDEmbedded ImageSDEmbedded ImageSD
Acetaldehyde75-07-00.0077*6e−056e−065e−056e−063e−051e−054e−064e−06
Acrylonitrile107-13-10.24*3e−056e−063e−058e−062e−057e−064e−063e−06
4-Aminobiphenyl92-67-1215e−079e−084e−074e−082e−076e−082e−079e−08
Arsenic7440-38-215*9e−073e−077e−072e−074e−072e−072e−08NA
Benzene71-43-20.027*9e−061e−069e−061e−066e−062e−061e−061e−06
Benzo[a]pyrene50-32-83.95e−078e−084e−075e−082e−076e−084e−085e−08
1,3-Butadiene106-99-00.11*4e−057e−064e−058e−062e−058e−065e−065e−06
Cadmium7440-43-96.3*5e−067e−073e−066e−072e−067e−073e−072e−07
Formaldehyde50-00-00.046*2e−053e−061e−054e−065e−062e−062e−062e−06
Lead7439-92-10.0421e−082e−091e−082e−095e−092e−093e−091e−10
NNK§64091-91-4494e−055e−063e−055e−062e−056e−064e−067e−07
N-Nitrosonornicotine80508-23-21.42e−063e−071e−063e−078e−073e−071e−076e−08
Quinoline§91-22-53*2e−058e−061e−054e−067e−062e−062e−061e−06
Cancer risk subtotals
    Human lung carcinogens*, Embedded Image5e−051e−054e−051e−052e−059e−064e−065e−06
    All cancers: Embedded Image2e−042e−052e−043e−051e−043e−052e−052e−05
  • NOTE: Conventional cigarettes classified by FTC tar yield as follows (30): regular, tar ≥ 15.0 mg; light, 6.0 mg ≤ tar < 15.0 mg; and ultralight, 1.0 ≤ tar < 6.0 mg. PREP cigarettes not characterized by tar content.

    Abbreviation: CASRN, Chemical Abstracts Registry Number.

  • * Integrated Risk Information System, U.S. Environmental Protection Agency (44).

  • Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. Sept. 2004 Cancer Potency List (46).

  • NA, not available; limited PREP yield data did not allow calculations for some chemicals. The mean (Embedded Image) for each chemical corresponds to a different number of PREPs because each PREP study measured different chemicals.

  • § CSF was determined from an oral exposure study.

  • CSF, 49 for all cancer end points. California Environmental Protection Agency. Sept. 2001 Expedited Cancer Potency Values and No Significant Risk Levels for Six Proposition 65 Carcinogens (47).

  • Embedded Image = sum of Embedded Image for known human lung carcinogens considered here: acrylonitrile, arsenic, cadmium, and formaldehyde.