Table 1.

Observations on smoking-related disease and risk assessment calculations

(a) Cigarette smoking causes considerable human disease, including many cases of lung cancer.
(b) Risk assessment methods use toxicant-by-toxicant exposure estimates to predict estimates of the incidence of cancer in humans.
(c) Cigarette yield data are available that give the per cigarette deliveries of some toxicants of interest in cigarette smoke.
(d) Risk assessment predictions of disease risk from smoking can be obtained based on available cigarette yield data for use in determining:
    (i) How the risk assessment-calculated risks compare among three types of conventional cigarettes (regular, light, ultralight) and for PREPs;
    (ii) How risk assessment-calculated risks for regular, light, and ultralight cigarettes comport with the observed levels of risk of smoking conventional cigarettes;
    (iii) Whether the risk assessment-predicted levels of risk for PREP cigarettes are meaningfully lower than risks from conventional cigarettes.