Table 2.

Adjusted RRs and 95% CIs of incident hematopoietic cancers and malignant gliomas according to aspartame intake levels derived from aspartame-containing beverages, the NIH-AARP Diet and Health Study, 1995-2000 (n = 473,984)

Aspartame intake (mg/d)All hematopoietic cancers
Gliomas*
Men and women combined
Men
Women
Men and women combined
Case, N = 1,888Person-yearsRR (95% CI)Case, N = 1,318Person-yearsRR (95% CI)Case, N = 570Person-yearsRR (95% CI)Case, N = 315RR (95% CI)
None869946,3161.00 (Referent)615585,9651.00 (Referent)254360,3511.00 (Referent)1621.00 (Referent)
>0, <100432505,2280.91 (0.81-1.03)294279,0470.95 (0.83-1.10)138226,1810.83 (0.67-1.02)830.99 (0.75-1.29)
≥100, <200280274,4301.10 (0.96-1.26)187158,7311.09 (0.92-1.29)93115,6991.11 (0.87-1.41)320.70 (0.48-1.03)
≥200, <400137148,0171.01 (0.84-1.21)9586,8001.03 (0.83-1.29)4261,2170.95 (0.68-1.32)160.66 (0.39-1.12)
≥400, <600104109,2621.05 (0.85-1.29)7670,0591.07 (0.84-1.36)2839,2041.02 (0.69-1.51)220.73 (0.46-1.15)
≥6006677,3570.98 (0.76-1.27)5149,9601.06 (0.79-1.42)1527,3980.80 (0.47-1.35)
P for trend0.560.420.870.05
  • NOTE: Cox proportional hazards regression model adjusted for age at entry (continuous), sex (for combined analysis), ethnicity (non–Hispanic White, non–Hispanic Black, others), BMI (weight in kilograms/height in meters squared; 4 categories of ≥18.5 and <25, ≥25 and <30, ≥30 and <35, and ≥35), and history of diabetes.

  • * Due to small numbers, aspartame categories of “≥400, <600” and “≥600” were collapsed for gliomas.