Table 2.

Effects of the selected polymorphisms on enzyme function and DNA adduct levels

PolymorphismEffect on enzymatic functionExpected effect on DNA adduct level
CYP1A2*1FHigher inducibilityIncreased bioactivation, higher adduct levels
GSTM1*0 delDeletion, no enzyme activityDecreased detoxification, higher adduct levels
GSTP1*2 I105VDecreased enzyme activityDecreased detoxification, higher adduct levels
*3 A114V
GSTT1*0 delDeletion, no enzyme activityDecreased detoxification, higher adduct levels
NAT2*5 I114TDecreased enzyme activityLess N-acetylation; decreased detoxification; higher adduct levels
*6 R197Q
*7 G286E
mEH*2 Y113HDecreased enzyme activityActs as phase II enzyme; decreased detoxification; increased adduct levels
*3 H139RIncreased enzyme activityActs as phase I enzyme; increased bioactiviation; increased DNA adduct levels
XRCC1*2 R194WIncreased enzyme activityIncreased repair capacity, lower adduct levels
*3 R280HDecreased enzyme activityReduced repair capacity, higher adduct levels
*4 Q399RDecreased enzyme activityReduced repair capacity, higher adduct levels
XRCC3*1 T241MDecreased enzyme activityReduced repair capacity, higher adduct levels
XPD*5 K751QDecreased enzyme activityReduced repair capacity, higher adduct levels
BRCA2*1 D991NDecreased enzyme activityReduced repair capacity, higher adduct levels
*3 N372H
NQO1*2 P187SReduced enzyme activityHigher DNA adduct levels
GPX1*1 P198LLess efficient final glutathione peroxidase complexHigher DNA adduct levels