Table 3.

Average tail moment per cell stratified by pesticide exposure status and various factors

VariablesControls
Pesticide exposure
nMean ± SELow
High
nMean ± SEnMean ± SE
All1061.33 ± 0.03431.92 ± 0.04482.35 ± 0.06*
Age (y)
    ≥52351.39 ± 0.06281.94 ± 0.05272.53 ± 0.08
    <52711.30 ± 0.03151.88 ± 0.06212.11 ± 0.08
Gender
    Male381.33 ± 0.04181.89 ± 0.06272.36 ± 0.08
    Female681.32 ± 0.04251.94 ± 0.05212.33 ± 0.10
Smoking status
    Current smokers151.31 ± 0.0572.01 ± 0.10112.03 ± 0.08
    Past smokers31.31 ± 0.1311.6332.43 ± 0.26
    Never smokers881.33 ± 0.03351.91 ± 0.04342.44 ± 0.08
Cumulative smoking dose (pack-years)
    >1071.36 ± 0.1161.88 ± 0.10112.20 ± 0.10
    ≤10991.32 ± 0.03371.92 ± 0.04372.39 ± 0.08
CYP3A5
    G−44G101.44 ± 0.1212.3412.79
    A−44G411.33 ± 0.05161.89 ± 0.06212.31 ± 0.10
    A−44A551.30 ± 0.02261.91 ± 0.05262.36 ± 0.09
PON1
    Gln-Gln431.28 ± 0.02121.93 ± 0.06212.38 ± 0.09
    Arg-Gln341.35 ± 0.05131.92 ± 0.07192.43 ± 0.10§
    Arg-Arg291.37 ± 0.12181.90 ± 0.0782.07 ± 0.18
PON2
    Cys-Cys21.38 ± 0.1722.02 ± 0.3712.87
    Cys-Ser321.27 ± 0.03111.99 ± 0.08152.30 ± 0.11
    Ser-Ser721.35 ± 0.04301.88 ± 0.04322.35 ± 0.08
GSTM1
    Null671.35 ± 0.04231.91 ± 0.05222.34 ± 0.09
    Non-null391.29 ± 0.03201.93 ± 0.06262.35 ± 0.09
GSTT1
    Null461.34 ± 0.05201.96 ± 0.05242.27 ± 0.10
    Non-null601.32 ± 0.03231.88 ± 0.05242.42 ± 0.08
GSTP1
    Ile-Ile561.37 ± 0.05271.93 ± 0.05302.45 ± 0.07
    Ile-Val431.27 ± 0.02141.87 ± 0.06162.22 ± 0.13
    Val-Val71.30 ± 0.0522.09 ± 0.3021.77 ± 0.02
  • NOTE: Values are in μm/cell. Comparison among different pesticide exposure groups is conducted with ANOVA, and comparison between different age, smoking status, and genotype groups is conducted with t test.

  • * P < 0.01; the high exposure group significantly different from the low pesticide exposure and control groups.

  • P < 0.01; compared with individuals ages <52 years in the high exposure group.

  • P = 0.03; compared with past and never smokers in the high exposure group.

  • § P = 0.08; compared with PON1 Arg-Arg genotypes in the high exposure group.

  • P = 0.03; compared with GSTP1 Ile-Val/Val-Val genotypes in the high exposure group.