Table 3.

Ovarian cancer survival in relation to pack-years of smoking, maximum number of cigarette per day, age when first smoked, and years since last smoked

All cases (n = 676)
Late FIGO stage (III and IV), n = 458
n*Adjusted HR (95% CI)n*Adjusted HR (95% CI)
Never smoked§4101.02831.0
Pack-years
    <10860.79 (0.56-1.10)590.80 (0.56-1.13)
    10-19541.18 (0.81-1.74)341.24 (0.82-1.86)
    20-29340.98 (0.61-1.60)221.08 (0.64-1.80)
    30+771.94 (1.41-2.66)491.98 (1.40-2.81)
P trend < 0.01P trend < 0.01
Maximum cigarettes/day
    <10380.93 (0.59-1.46)260.93 (0.58-1.50)
    10-19641.05 (0.74-1.50)461.10 (0.75-1.59)
    20-29801.03 (0.74-1.44)500.98 (0.68-1.42)
    30+711.93 (1.37-2.73)432.06 (1.43-2.98)
P trend < 0.01P trend < 0.01
Age first smoked (y)
    <16361.50 (0.93-2.41)221.69 (1.01-2.84)
    16-191101.25 (0.95-1.66)711.20 (0.88-1.64)
    20-24631.07 (0.74-1.53)431.10 (0.76-1.60)
    25+471.02 (0.68-1.53)311.07 (0.70-1.66)
P trend = 0.30P trend = 0.28
Years since last smoked
    <10461.32 (0.85-2.04)281.40 (0.88-2.25)
    10-19441.22 (0.83-1.79)301.13 (0.73-1.74)
    20+490.80 (0.54-1.16)410.74 (0.50-1.10)
P trend = 0.07P trend = 0.01
    Per 5 years1.01 (0.92-1.12)
    Per 5 years0.98 (0.88-1.09)
  • * Column numbers (n) do not sum to total because some data are missing (pack-years, 5% missing; maximum cigarettes per day, 5% missing; age first smoked, 4% missing; and years since last smoked, 4% missing).

  • Adjusted for age, stage, histologic subtype and grade, residual disease, platinum-based chemotherapy, and usual BMI.

  • Adjusted for age, histologic subtype and grade, residual disease, platinum-based chemotherapy, and usual BMI.

  • § Reference category.

  • Adjusted for age, stage, histologic subtype and grade, residual disease, platinum-based chemotherapy, usual BMI, and pack-years of smoking.

  • Adjusted for age, histologic subtype and grade, residual disease, platinum-based chemotherapy, usual BMI, and pack-years of smoking.