Table 1.

DIM pharmacokinetic data from acute and chronic single doses of I3C

I3C dose (mg)nCmax (ng/mL)tmax (h)AUC (0-24 h) (h ng/mL)t1/2 (h)
400461 ± 12 (50-77)3.0 ± 1.2329 ± 59 (271-400)*3.8 ± 0.3
600493 ± 30 (54-127)2.2 ± 1.2364 ± 136 (124-502)2.0 ± 0.7
8004262 ± 109 (144-408)2.0 ± 0.01,608 ± 662 (660-2,411)4.2 ± 1.9
1,0003607 ± 561 (274-1,255)2.0 ± 0.03,376 ± 3,542 (698-7,451)5.7 ± 0.1
1,2008510 ± 248 (262-1,025)2.5 ± 0.93,212 ± 1,380 (1,638-5,153)5.0 ± 3.1
400 mg (chronic)1469 ± 42 (11-139)1.3 ± 1.4372 ± 180 (107-688)6.0 ± 4.5
  • NOTE: Data are presented as mean ± SD. Values in parentheses for Cmax and AUC denote the range (minimum-maximum) of individual values.

  • * Sampling period for the acute 400-mg dose of I3C was from 0-8 h, as opposed to 0-24 h for subsequent dosing groups.