Table 1.

CYP phenotypic indices before and after 4 weeks of daily Polyphenon E administration

CYP isozymePhenotypic indexIndex values*
P
BaselinePosttreatment
CYP1A2Paraxanthine/caffeine ratio in 4-h postdose plasma (n = 41)0.28 ± 0.13 (0.05-0.6)0.29 ± 0.16 (0.03-0.84)0.75
CYP3A4Buspirone AUC min·ng/ml (n = 41)136.7 ± 115.7 (15.2-626.7)166.0 ± 137.7 (10.5-545.3)0.01
CYP2D6Dextromethorphan/dextrorphan molar ratio in 0-8 h postdose urine (n = 32)0.22 ± 0.69 (0.00058-3.33)0.21 ± 0.52 (0.00027-2.23)0.47
CYP2C9Losartan/E3174 ratio in 0-8 h postdose urine (n = 42)1.53 ± 1.07 (0.38-4.75)1.52 ± 1.07 (0.24-5.86)0.84
  • * Mean ± SD (range).