Table 4.

Risk of colorectal cancer associated with thirds of red meat intake and ERCC6 genotype

Red meat intake (g/d)
Pinteraction*
<44.044.0-<86.3≥86.3
All participants1.01.16 (0.80-1.70)1.32 (0.86-2.02)
M1097V
    MM1.01.05 (0.64-1.72)1.18 (0.69-2.03)
    MV or VV1.36 (0.79-2.34)1.67 (0.96-2.87)2.27 (1.29-3.99)0.33
R1213G
    RR1.01.01 (0.61-1.65)1.10 (0.64-1.89)
    RG or GG1.13 (0.65-1.97)1.68 (0.99-2.86)2.04 (1.16-3.60)0.20
  • NOTE: RRs are based on the 202 cases and 1,583 subcohort participants with information on diet and are adjusted for age, race, and energy.

  • * P for interaction estimated using a likelihood ratio test and assuming linearity for thirds of red meat intake.