Table 2.

Multivariate relative risk (95% confidence interval) of melanoma by site in the combined data set of the NHS, NHS II, and HPFS

Head or neckTrunk, shoulder, hip, back, or abdomenUpper extremityLower extremityP for difference by body site
Number of cases4918898176
Sex
    Women1.001.001.001.00
    Men4.74 (2.44-9.21)2.68 (1.81-3.96)0.96 (0.48-1.91)0.68 (0.38-1.24)<0.0001
Age (for 5-y increase)1.15 (1.01-1.32)1.10 (1.03-1.18)1.06 (0.96-1.17)1.05 (0.98-1.13)0.63
Family history of melanoma
    No1.001.001.001.00
    Yes2.37 (0.85-6.60)2.42 (1.46-3.99)1.35 (0.55-3.32)2.20 (1.27-3.80)0.71
History of severe and painful sunburn (no. of burns)
    No1.001.001.001.00
    1-21.98 (0.62-6.32)1.20 (0.75-1.94)2.88 (1.06-7.82)1.23 (0.74-2.03)
    3-52.73 (0.88-8.43)1.09 (0.66-1.82)3.68 (1.36-9.99)1.50 (0.90-2.49)
    6-93.16 (0.98-10.18)1.52 (0.90-2.56)6.40 (2.39-17.10)1.21 (0.67-2.17)
    10+2.42 (0.76-7.68)1.67 (1.03-2.71)6.86 (2.62-18.00)2.09 (1.27-3.45)
P for trend0.120.02<0.00010.0060.04
Number of moles of >3 mm diameter on arms (lower legs in the NHS II)
    No1.001.001.001.00
    1-21.30 (0.62-2.76)1.03 (0.67-1.59)1.83 (1.12-3.01)0.98 (0.65-1.47)
    3-52.64 (1.17-5.95)2.94 (1.94-4.46)2.94 (1.65-5.21)2.26 (1.48-3.46)
    6-92.35 (0.70-7.89)3.58 (2.13-6.03)2.31 (0.97-5.50)2.13 (1.18-3.84)
    10+3.45 (1.36-8.79)4.67 (3.07-7.11)2.50 (1.22-5.15)2.00 (1.20-3.32)
P for trend0.002<0.00010.0003<0.00010.04
Hair color
    Black or dark brown0.96 (0.51-1.81)0.58 (0.40-0.82)0.95 (0.60-1.51)0.86 (0.61-1.20)
    Light brown1.001.001.001.00
    Blonde1.08 (0.45-2.60)1.51 (1.05-2.19)1.28 (0.72-2.28)0.79 (0.49-1.29)
    Red1.71 (0.50-5.86)2.00 (1.15-3.50)2.13 (1.02-4.45)2.16 (1.27-3.69)
P for trend0.47<0.00010.060.050.08
  • NOTE: Data are adjusted for all of the variables in the table simultaneously.