Table 4.

Association of BMI, physical activity, and postmenopausal hormone use and colorectal cancer risk stratified by IGFBP-3 genotype

n Cases (%)
CC
CG
GG
CCCCGGOR (95% CI)OR (95% CI)OR (95% CI)
BMI
    Males
        <26.541 (40.2)62 (39.5)30 (39.5)1.00.6 (0.3-1.2)0.5 (0.2-1.1)
        26.5+61 (59.8)95 (60.5)46 (60.5)0.8 (0.4-1.6)1.0 (0.5-2.0)3.3 (1.1-9.4)*
        Pinteraction<0.01
    Females
        <25.670 (48.0)86 (42.2)45 (46.9)1.00.9 (0.5-1.5)0.8 (0.4-1.4)
        25.6+76 (52.1)118 (57.8)51 (53.1)0.9 (0.5-1.4)1.2 (0.7-1.9)1.8 (1.0-3.5)*
        Pinteraction0.06
Vigorous physical activity (h/mo)
    Males
        044 (43.1)86 (54.8)34 (44.7)1.01.2 (0.5-1.5)0.7 (0.3-1.6)
        Low35 (34.3)43 (27.4)23 (30.3)0.9 (0.4-2.1)0.7 (0.3-1.7)1.6 (0.5-4.7)
        High23 (22.6)28 (17.8)19 (25.0)0.6 (0.2-1.7)0.4 (0.2-1.0)*2.5 (0.7-9.3)
        Pinteraction<0.01
    Females
        070 (48.0)106 (52.0)45 (46.4)1.01.2 (0.7-2.1)1.2 (0.6-2.3)
        Low39 (26.7)46 (22.6)32 (33.0)0.9 (0.5-1.7)0.8 (0.4-1.4)1.4 (0.7-2.8)
        High37 (25.3)52 (25.5)20 (20.6)0.7 (0.4-1.3)0.9 (0.5-1.6)0.7 (0.3-1.5)
        Pinteraction0.98
Postmenopausal hormone use
    Never58 (46.0)77 (42.8)44 (56.4)1.01.1 (0.6-1.9)2.1 (1.0-4.4)*
    Former12 (9.5)18 (10.0)12 (15.4)0.9 (0.3-2.4)1.4 (0.6-3.5)1.0 (0.4-2.6)
    Current56 (44.4)85 (47.2)22 (28.2)1.1 (0.6-1.9)1.1 (0.6-2.0)0.6 (0.3-1.2)
    Pinteraction0.01
  • NOTE: Adjusted for age, race/ethnicity, any sigmoidoscopy, family history of colorectal cancer, smoking status, NSAID use, physical activity, BMI, and postmenopausal hormone use.

  • * P < 0.05.

  • Among postmenopausal women.