Table 3.

Association of BMI, physical activity, and postmenopausal hormone use and colorectal cancer risk stratified by IGF-1 genotype

n Cases (%)
19/19
Other
19/19OtherOR (95% CI)OR (95% CI)
BMI
    Males
        <26.554 (39.1)79 (40.1)1.01.0 (0.5-1.9)
        26.5+84 (60.9)118 (59.9)1.9 (1.0-3.7)*1.6 (0.9-2.8)
        Pinteraction0.63
    Females
        <25.665 (41.1)136 (47.2)1.02.3 (1.5-3.6)*
        25.6+93 (58.9)152 (52.8)2.0 (1.2-3.2)*2.1 (1.4-3.3)*
        Pinteraction0.02*
Vigorous physical activity (h/mo)
    Males
        065 (47.1)99 (50.3)1.01.1 (0.6-2.1)
        Low40 (29.0)61 (31.0)1.1 (0.5 2.3)0.9 (0.4 1.9)
        High33 (23.9)37 (18.8)0.8 (0.4 1.8)0.6 (0.3-1.3)
        Pinteraction0.46
    Females
        069 (43.7)152 (52.6)1.01.8 (1.1-2.9)*
        Low46 (29.1)71 (24.6)1.1 (0.6-2.0)1.2 (0.7-2.1)
        High43 (27.2)66 (22.8)0.7 (0.4-1.3)1.2 (0.7-2.1)
        Pinteraction0.80
Postmenopausal hormone use
    Never65 (47.5)114 (46.2)1.01.6 (0.9-2.6)
    Former16 (11.7)26 (10.5)0.8 (0.3-1.7)1.9 (0.8-4.2)
    Current56 (40.9)107 (43.3)0.9 (0.5-1.5)1.2 (0.7-2.0)
    Pinteraction0.78
  • NOTE: Adjusted for age, race/ethnicity, any sigmoidoscopy, family history of colorectal cancer, smoking status, NSAID use, physical activity, BMI, and postmenopausal hormone use (women).

  • * P < 0.05.

  • Among postmenopausal women.