Table 3.

SIRs and 95% CIs for cancers of the larynx and pharynx in patients with heartburn, hiatal hernia, or esophagitis according to indicators of severity and specificity of diagnosis

CharacteristicsTotal
Without alcoholism
Laryngeal carcinoma
Pharyngeal Carcinoma
Laryngeal carcinoma
Pharyngeal carcinoma
Number of cases, relative risk* (95% CI)
Diagnosis
    Heartburn0, — (—)0, — (—)0, — (—)0, — (—)
    Hiatal hernia20, 2.3 (1.4-3.6)9, 1.2 (0.6-2.3)19, 2.4 (1.4-3.7)3, 0.4 (0.1-1.3)
    Esophagitis10, 1.0 (0.5-1.8)22, 2.6 (1.6-3.9)4, 0.4 (0.1-1.1)11, 1.5 (0.7-2.6)
Diagnosed in Otolaryngology or Surgery Department
    Yes16, 1.5 (0.8-2.4)22, 2.5 (1.6-3.8)10, 1.0 (0.5-1.9)9, 1.1 (0.5-2.1)
    No14, 1.7 (0.9-2.8)9, 1.3 (0.6-2.4)13, 1.7 (0.9-2.9)5, 0.8 (0.3-1.8)
Diagnosis by endoscopy
    Yes10, 1.4 (0.7-2.6)14, 2.5 (1.3-4.1)6, 1.0 (0.4-2.1)4, 0.8 (0.2 -2.0)
    No20, 1.6 (1.0-2.5)17, 1.7 (1.0-2.6)17, 1.5 (0.9-2.4)10, 1.1 (0.5-1.9)
Reflux as primary or non-primary diagnosis
    Never primary diagnosis18, 2.3 (1.3-3.6)9, 1.4 (0.6-2.6)15, 2.1 (1.2-3.4)5, 0.8 (0.3-1.9)
    Primary reflux diagnosis12, 1.1 (0.6-1.9)22, 2.4 (1.5-3.6)8, 0.8 (0.3-1.5)9, 1.1 (0.5-2.0)
        Never admitted as emergency case4, 0.8 (0.2-2.4)8, 2.0 (0.9-4.0)2, 0.5 (0.1-1.6)4, 1.1 (0.3-2.8)
        Admitted as emergency case8, 1.2 (0.5-2.4)14, 2.6 (1.4-4.3)6, 1.1 (0.4-2.3)5, 1.1 (0.3-2.5)
  • * Relative risks were calculated as SIRs.