Table 1.

ORs and 95% CIs of bladder cancer according to history of gastric and duodenal ulcer, Italy, 1985 to 1992

Gastric ulcer
Duodenal ulcer
Cases/controlsOR (95% CI)*OR (95% CI)Cases/controlsOR (95% CI)*OR (95% CI)
Never671/1,00711643/97011
Ever55/601.26 (0.84-1.87)1.19 (0.79-1.80)84/971.15 (0.84-1.59)1.14 (0.81-1.59)
Time since ulcer diagnosis (years)
    <1516/240.96 (0.49-1.88)0.92 (0.46-1.83)22/350.96 (0.55-1.69)0.96 (0.53-1.73)
    15-2921/211.38 (0.72-2.62)1.27 (0.66-2.45)36/291.63 (0.97-2.74)1.62 (0.95-2.77)
    ≥3018/151.53 (0.75-3.13)1.50 (0.72-3.13)26/330.94 (0.55-1.61)0.90 (0.52-1.57)
    χ2, trend§0.63 (P = 0.43)0.48 (P = 0.49)0.18 (P = 0.67)0.25 (P = 0.62)
Age at ulcer diagnosis (years)
    <3011/181.03 (0.47-2.26)1.02 (0.46-2.25)14/280.77 (0.39-1.51)0.80 (0.40-1.59)
    30-4419/171.75 (0.87-3.52)1.83 (0.89-3.78)36/371.42 (0.87-2.33)1.41 (0.84-2.35)
    ≥4525/251.11 (0.62-1.99)0.98 (0.54-1.78)34/321.17 (0.70-1.94)1.12 (0.67-1.90)
    χ2, trend§0.11 (P = 0.73)0.30 (P = 0.59)0.55 (P = 0.46)0.37 (P = 0.55)
Calendar year of ulcer diagnosis
    Before 195515/82.17 (0.90-5.23)2.03 (0.83-4.94)20/221.12 (0.59-2.10)1.09 (0.57-2.08)
    1955-196412/141.23 (0.55-2.77)1.16 (0.51-2.67)19/221.24 (0.65-2.37)1.25 (0.65-2.41)
    1965-197412/161.07 (0.48-2.36)1.02 (0.45-2.32)24/201.41 (0.75-2.64)1.35 (0.70-2.59)
    1975 or after16/221.02 (0.52-2.02)0.97 (0.48-1.96)21/330.94 (0.53-1.69)0.95 (0.52-1.74)
    χ2, trend§0.93 (P = 0.34)0.62 (P = 0.43)0.002 (P = 0.97)0.04 (P = 0.85)
  • * ORs adjusted for age, sex, and study center.

  • ORs adjusted for age, sex, study center, education, smoking habit, coffee consumption, and occupational exposure to potential bladder carcinogens (i.e., chemical industry, dyestuff, painting, pharmaceutical, coal, and gas).

  • Reference category.

  • § Based only on subjects with a history of the disease.