Table 3.

Data-dredging gene-dose analyses, permutation-corrected, with different number of loci and different sample sizes

Number of high-risk genotypesSample size (500)
Sample size (1,000)
OR*Coverage probability of the CIOR*Coverage probability of the CI
Three loci
    Number of high-risk genotypes
        0 to 11.00001.0000
        21.00150.94871.00000.9454
        31.00190.95281.00320.9519
    Type I error rate of the trend test0.05100.0531
Five loci
    Number of high-risk genotypes
        0 to 11.00001.0000
        2 to 30.99910.94591.00250.9506
        4 to 51.00140.94781.00140.9532
    Type I error rate of the trend test0.04940.0456
Ten loci
    Number of high-risk genotypes
        0 to 31.00001.0000
        4 to 60.99960.94930.99970.9475
        7 to 100.99820.94961.00200.9491
    Type I error rate of the trend test0.04880.0498
  • NOTE: The results are based on 10,000 simulations, with 1,000 permutations for each round of the simulation. Other settings are the same as those in Table 2.

  • * Geometric mean of 10,000 simulations.