Table 1.

A sample of data-dredging gene-dose analysis in the literature

Citations*Genes studiedNumber of lociUnit of analysisFindings
Chiu et al., CEBP 2002;11:646–53collagen-related genes6genotypeincreased risk of oral submucous fibrosis with increasing number of high-risk genotypes (P < 0.05)
Cho et al., CEBP 2003;12:1100–4DNA repair genes2genotypeOR (for nasopharyngeal carcinoma) = 3.0 for subjects with two high-risk genotypes
Fu et al., Cancer Res 2003;63:2440–6DNA repair genes5genotypea 1.46-fold increase in risk for breast cancer with one additional high-risk genotype
Gu et al., Clin Cancer Res 2005;11:1408–15DNA repair genes8alleleincreased risk of bladder cancer recurrence with increasing number of high-risk alleles (P < 0.001)
Han et al., Cancer Res 2004;64:3009–13DNA repair genes5alleledecreased risk of nonmelanoma skin cancer with increasing number of low-risk alleles (P < 0.05)
Hu et al., Int J Cancer 2005;115:478–83DNA repair genes2genotypeOR (for lung cancer) = 2.41 for subjects with two high-risk genotypes
Koh et al., Carcinogenesis 2005;26:459–64angiotensin-related genes3genotypedecreased risk of breast cancer with increasing number of low-risk genotypes (P = 0.05)
Li et al., Carcinogenesis 2005;26:1596–602cell-cycle control genes2alleleincreased risk of squamous cell carcinoma with increasing number of high-risk alleles (P = 0.001)
Sturgis et al., Carcinogenesis 1999;20:2125–9DNA repair genes2genotypeOR (for squamous cell carcinoma) = 2.02 for subjects with two high-risk genotypes
Zhang et al., CEBP 2005;14:1188–93folate metabolism genes2alleleincreased risk of squamous cell carcinoma with increasing number of high-risk alleles (P = 0.002)
  • * CEBP, Cancer Epidemiology Biomarkers and Prevention; Cancer Res, Cancer Research; Clin Cancer Res, Clinical Cancer Research; Int J Cancer, International Journal of Cancer.