Table 2.

The association between the AR CAG and PSA ARE-I −158 G/A polymorphisms and breast cancer in African-American women

CAG length (S <22; L ≥22)Cases, n (%)Controls, n (%)OR (95% CI)
All womenSS145 (60.7)156 (62.7)1.0
SL or LL94 (39.3)93 (37.3)1.09 (0.75-1.57)
Menopausal status
    PremenopausalSS43 (59.7)51 (62.2)1.0
SL or LL29 (40.3)31 (37.8)1.11 (0.58-2.12)
    PostmenopausalSS90 (61.6)90 (61.6)1.0
SL or LL56 (38.4)56 (38.4)1.01 (0.63-1.61)
P for interaction = 0.82
First-degree family history
    YesSS18 (51.4)25 (78.1)1.0
SL or LL17 (48.6)7 (21.9)3.18 (1.08-9.36)
    NoSS127 (62.3)131 (60.4)1.0
SL or LL77 (37.7)86 (39.6)0.92 (0.62-1.37)
P for interaction = 0.03
ARE-I genotypesCases n (%)Controls n (%)OR (95% CI)
All womenAA65 (27.2)68 (27.3)1.0
AG125 (52.3)132 (53.0)0.98 (0.65-1.50)
GG49 (20.5)49 (19.7)1.04 (0.62-1.76)
P for trend = 0.90
Menopausal status
    PremenopausalAA26 (36.1)28 (34.1)1.0
AG31 (43.1)44 (53.7)0.75 (0.37-1.52)
GG15 (20.8)10 (12.2)1.81 (0.68-4.84)
P for trend = 0.46
    PostmenopausalAA32 (21.9)37 (25.3)1.0
AG86 (58.9)74 (50.7)1.33 (0.76-2.35)
GG28 (19.2)35 (24.0)0.92 (0.47-1.84)
P for trend = 0.86
P for interaction = 0.10
First-degree family history
    YesAA10 (28.6)8 (25.0)1.0
AG18 (51.4)19 (59.4)0.80 (0.25-2.51)
GG7 (20.0)5 (15.6)1.05 (0.24-4.68)
P for trend = 0.99
    NoAA55 (27.0)60 (27.6)1.0
AG107 (52.5)113 (52.1)1.04 (0.66-1.63)
GG42 (20.6)44 (20.3)1.05 (0.60-1.84)
P for trend = 0.86
P for interaction = 0.82