Table 3.

Interplay between cruciferous vegetable intake (g/wk), GSTP1 and GSTA1 genotype, and the risk of colorectal adenomas in subgroups of age and sex

Crucifer intake (g/wk)*
n (cases/controls)
OR (95% CI), P for interaction
n (cases/controls)
OR (95% CI), P for interaction
≤129
>129
≤129
>129
≤129
>129
≤129
>129
Age
≤55 y§
>55 y§
All genotypes119/205134/19511.14 (0.82-1.59)217/144276/15411.17 (0.86-1.58)
    GSTP1
        GG11/2115/2711.10 (0.41-2.94)23/2241/1313.22 (1.35-7.69)
        AG51/10459/760.93 (0.41-2.09)1.38 (0.61-3.15)100/65124/711.50 (0.76-2.93)1.61 (0.83-3.14)
        AA55/8057/921.26 (0.56-2.86)1.13 (0.50-2.56)93/57109/701.54 (0.78-3.05)1.45 (0.74-2.84)
0.340.040
    GSTA1
        TT14/3927/3512.31 (1.03-5.18)39/2455/2811.22 (0.61-2.45)
        CT63/9555/912.00 (0.99-4.04)1.58 (0.77-3.22)103/74132/690.90 (0.50-1.65)1.19 (0.65-2.17)
        CC41/7149/691.58 (0.76-3.29)2.12 (1.02-4.40)72/4687/570.98 (0.52-1.85)0.95 (0.51-1.77)
0.0600.67
Sex
Male
Female
All genotypes190/145209/12211.24 (0.89-1.72)146/204201/22711.05 (0.77-1.44)
    GSTP1
        GG18/19
24/7
1
3.75 (1.25-11.2)
16/24
32/33
1
1.33 (0.57-3.08)
        AG80/73101/541.25 (0.59-2.62)1.99 (0.94-4.22)71/9682/931.16 (0.55-2.44)1.14 (0.54-2.39)
        AA91/5382/611.93 (0.91-4.09)1.45 (0.68-3.06)57/8484/1011.04 (0.49-2.22)1.12 (0.54-2.35)
0.00950.82
    GSTA1
        TT35/29
38/21
1
1.37 (0.65-2.92)
18/34
44/42
1
1.72 (0.81-3.64)
        CT83/63103/611.06 (0.57-1.95)1.38 (0.75-2.54)83/10684/991.49 (0.76-2.90)1.29 (0.66-2.54)
        CC70/5366/401.16 (0.62-2.18)1.25 (0.65-2.41)43/6470/861.19 (0.58-2.45)1.35 (0.68-2.70)
0.830.28
  • * Mean cruciferous vegetable intake was 73.1 ± 36.3 and 70.3 ± 36.6 g/wk for cases and controls, respectively, in the lower-than-median intake group; and 242.5 ± 108.4 and 230.3 ± 109.2 g/wk, respectively, in the higher-than-median intake group.

  • Adjusted for age (in 4 categories: <45, <55, <65, <75 y), sex, energy intake (kJ/d) and folate intake (g/d), if applicable.

  • Calculated as the LR test comparing the models with and without crucifer-by-genotype interaction terms.

  • § Age in the lower and higher age category was 44.1 ± 8.8 and 64.7 ± 5.6 years, respectively.

  • Least active/expressed variant(s).