Table 3.

Multivariate RR of colon cancer by site in relation to intakes of GL, GI, carbohydrate, and fructose in the NHS (1980-2000) and HPFS (1986-2000)

Quintiles of intake
P
1234595% CI*
GI
Men
    Proximal (n = 227)1.00.961.151.180.99 0.63-1.570.72
    Distal (n = 228)1.01.301.091.011.06 0.67-1.680.91
Women
    Proximal (n = 403)1.00.851.191.151.11 0.77-1.580.27
    Distal (n = 326)1.00.811.020.920.91 0.63-1.340.82
GL
Men
    Proximal1.00.971.351.061.10 0.64-1.880.67
    Distal1.01.011.221.150.87 0.51-1.490.85
Women
    Proximal1.01.060.960.580.770.53-1.110.02
    Distal1.00.901.140.890.90 0.60-1.360.59
Carbohydrate
Men
    Proximal1.01.171.261.091.11 0.64-1.930.81
    Distal1.00.880.991.010.86 0.50-1.470.73
Women
    Proximal1.01.060.950.670.63 0.42-0.950.01
    Distal1.01.041.251.100.95 0.61-1.500.85
Sucrose
Men
    Proximal1.01.181.161.491.17 0.73-1.890.41
    Distal1.01.121.091.231.14 0.72-1.790.54
Women
    Proximal1.00.930.790.750.73 0.51-1.030.04
    Distal1.01.601.311.231.34 0.89-2.020.60
Fructose
Men
    Proximal1.00.971.251.331.19 0.74-1.910.31
    Distal1.01.141.151.071.30 0.82-2.040.34
Women
    Proximal1.01.090.980.700.83 0.58-1.170.06
    Distal1.00.700.790.850.79 0.55-1.140.48
  • NOTE: Multivariate RRs are relative risks adjusted for age, family history of colon cancer, prior endoscopy screening, aspirin use, height, BMI, pack-years of smoking before age 30, physical activity, and intakes of cereal fiber, alcohol, calcium, folate, processed meat and beef, pork or lamb as main dish.

  • * 95% CI for q5 versus q1.

  • Numbers of proximal plus distal cases do not add up to colon cancer cases in Table 2 because colon cases include those for which we could not identify subsite.