Table 2.

Multivariate relative risk of colorectal cancer in relation to intakes of GL, GI, carbohydrate, and fructose in the NHS (1980-2000) and HPFS (1986-2000)

Quintiles of intake
P
1234595% CI*
GI
Men
Index/d6974767882
    Colorectal (n = 683)1.01.061.091.081.140.88-1.480.33
    Colon (n = 552)1.01.111.161.131.130.84-1.510.40
    Rectal (n = 131)1.00.910.850.891.210.68-2.150.65
Women
    Index/d6571747781
    Colorectal (n = 1,096)1.00.841.021.001.080.87-1.340.27
    Colon (n = 858)1.00.821.101.041.060.83-1.360.29
    Rectal (n = 238)1.00.910.750.881.140.73-1.780.70
GL
Men
    Load/d131158177195223
    Colorectal1.01.131.361.361.320.98-1.790.04
    Colon1.01.071.421.321.250.88-1.250.11
    Rectal1.01.321.071.481.610.82-3.170.17
Women
    Load/d80103119137167
    Colorectal1.01.031.100.910.890.71-1.110.15
    Colon1.01.061.080.790.890.69-1.150.11
    Rectal1.00.931.191.400.870.52-1.440.95
Carbohydrate
Men
    g/d182214234256288
    Colorectal1.01.111.211.241.270.93-1.720.11
    Colon1.01.051.231.221.210.85-1.710.20
    Rectal1.01.311.091.291.450.73-2.380.34
Women
    g/d110137155174202
    Colorectal1.01.071.110.940.870.68-1.110.15
    Colon1.01.071.090.880.860.65-1.130.14
    Rectal1.01.091.181.180.910.53-1.550.78
Sucrose
Men
    g/d2636445367
    Colorectal1.01.151.191.401.300.99-1.690.03
    Colon1.01.181.201.361.250.93-1.680.13
    Rectal1.01.071.211.621.470.81-2.660.11
Women
    g/d1726334155
    Colorectal1.01.050.980.980.890.72-1.110.10
    Colon1.01.171.000.980.990.78-1.260.49
    Rectal1.00.690.900.970.620.39-0.990.17
Fructose
Men
    g/d2940485672
    Colorectal1.01.021.191.261.371.05-1.780.008
    Colon1.01.011.251.251.381.03-1.860.02
    Rectal1.01.130.991.281.310.72-2.380.33
Women
    g/d2233415068
    Colorectal1.00.940.930.800.870.71-1.070.20
    Colon1.00.920.880.800.860.68-1.090.15
    Rectal1.01.031.150.810.920.59-1.440.47
  • NOTE: Multivariate RRs are relative risks adjusted for age, family history of colon cancer, prior endoscopy screening, aspirin use, height, BMI, pack-years of smoking before age 30, physical activity, and intakes of cereal fiber, alcohol, calcium, folate, processed meat and beef, pork or lamb as main dish.

  • * 95% CI for q5 versus q1.

  • Intakes are provided for medians of quintiles.