Table 3.

Associations between prevalent type 2 DM and incident CRC, overall and by anatomic subsite: IWHS, 1986 to 1999

Type 2 DM*CRC RISK
Overall
Proximal colon
Distal colon
Rectum
Cases (person-years)RR (95% CI)Cases (person-years)RR (95% CI)Cases (person-years)RR (95% CI)Cases (person-years)RR (95% CI)
No DM (n = 33,072)804 (419,681)1.0 (—)362 (419,565)1.0 (—)243 (419,863)1.0 (—)187 (422,505)1.0 (—)
Prevalent DM (n = 1,900)66 (21,686)1.4 (1.1-1.8)40 (21,682)1.9 (1.3-2.6)16 (21,750)1.1 (0.6-1.8)9 (21,885)0.8 (0.4-1.6)
  • * Prevalent type 2 (age of onset >30 years) DM status determined by self-report at baseline.

  • Multivariate risk estimates (95% CIs) accounting for age, BMI, total energy intake, calcium intake and vitamin E intake using continuous and categorical variables as defined in Table 1.