Table 5.

Association between NER haplotypes and endometrial cancer, by gene

Haplotypes*Frequency
OR (95% CI)
CasesControls
ERCC1 (C8092A and C19007T)
    000.600.63Reference
    100.010.011.48 (0.49-4.46)
    010.140.121.19 (0.87-1.61)
    110.240.241.01 (0.79-1.29)
ERCC2 (D312N, K751Q, and C22541A)
    0000.150.16Reference
    1000.060.041.48 (0.88-2.50)
    0100.060.060.99 (0.59-1.67)
    0010.410.401.06 (0.79-1.43)
    1100.290.301.00 (0.73-1.36)
    0110.020.020.96 (0.44-2.10)
ERCC4 (R415Q and T30028C)
    000.720.71Reference
    010.210.220.92 (0.72-1.18)
    110.080.061.16 (0.77-1.75)
XPC (A499V and K939Q)
    000.360.33Reference
    100.260.290.82 (0.64-1.05)
    010.380.370.93 (0.74-1.17)
  • * For each haplotype, 0 = common allele and 1 = rare allele for each SNP (in the order listed).

  • Adjusted for age at reference date (50-54, 55-59, 60-64, and 65-69 y) and county of residence (King, Pierce, and Snohomish).