Table 4.

Risk of endometrial cancer, by ERCC1-ERCC4 heterodimer and XPA genotypes

ERCC1-ERCC4*XPA G23ANo. cases (%), n = 371No. controls (%), n = 420OR (95% CI)
0GG36 (57.1)39 (45.9)Reference
GA/AA27 (42.9)46 (54.1)0.77 (0.36-1.65)
1GG40 (46.5)52 (50.5)Reference
GA/AA46 (53.5)51 (49.5)1.25 (0.65-2.40)
2GG72 (54.1)55 (41.0)Reference
GA/AA61 (45.9)79 (59.0)0.52 (0.30-0.90)
3GG35 (53.8)25 (35.2)Reference
GA/AA30 (46.2)46 (64.8)0.35 (0.16-0.80)
4GG12 (50.0)14 (51.8)Reference
GA/AA12 (50.0)13 (48.2)0.98 (0.22-4.36)
  • * ERCC1-ERCC4 heterodimer: values represent the number of sites with at least one rare allele across the two genes of the heterodimeric complex (ERCC1 8092, ERCC1 19007, ERCC4 415, and ERCC4 30028).

  • Adjusted for age at reference date (50-54, 55-59, 60-64, and 65-69 y) and county of residence (King, Pierce, and Snohomish).