Table 3.

Risk of endometrial cancer in relation to the number of rare alleles within a given gene

Gene*Frequency
OR (95% CI)
Cases (%), n = 371Controls (%), n = 420
ERCC1 (C8092A and C19007T)
    0131 (35.3)165 (39.3)Reference
    177 (20.8)75 (17.9)1.27 (0.86-1.89)
    2163 (43.9)180 (42.9)1.09 (0.79-1.49)
ERCC2 (D312N, K751Q, and C22541A)
    0-1128 (34.5)154 (36.7)Reference
    2150 (40.4)160 (38.1)1.10 (0.79-1.52)
    393 (25.1)106 (25.2)1.03 (0.72-1.49)
ERCC4 (R415Q and T30028C)
    0186 (50.1)214 (51.0)Reference
    1130 (35.0)155 (36.9)0.95 (0.70-1.29)
    255 (14.8)51 (12.1)1.21 (0.78-1.86)
XPC (A499V and K939Q)
    059 (15.9)48 (11.4)Reference
    1246 (66.3)281 (66.9)0.70 (0.46-1.07)
    266 (17.8)91 (21.7)0.58 (0.35-0.96)
  • * Values represent the number of sites with at least one rare allele across each of the respective SNPs for each gene.

  • Adjusted for age at reference date (50-54, 55-59, 60-64, and 65-69 y) and county of residence (King, Pierce, and Snohomish).