Table 2.

Distribution of nucleotide excision repair genotypes among cases and controls

Gene/polymorphismNo. cases (%), n = 371No. controls (%), n = 420OR (95% CI)*
ERCC1 C8092A
    CC205 (55.3)235 (56.0)Reference
    CA/AA166 (44.7)185 (44.0)0.99 (0.75-1.32)
        CA142 (38.3)159 (37.9)1.00 (0.74-1.34)
        AA24 (6.5)26 (6.2)0.97 (0.54-1.75)
ERCC1 C19007T
    CC134 (36.1)170 (40.5)Reference
    CT/TT237 (63.9)250 (59.5)1.16 (0.86-1.55)
        CT188 (50.7)196 (46.7)1.19 (0.88-1.61)
        TT49 (13.2)54 (12.9)1.04 (0.66-1.64)
ERCC2 D312N (G > A)
    DD152 (41.0)186 (44.3)Reference
    DN/NN219 (59.0)234 (55.7)1.13 (0.85-1.51)
        DN173 (46.6)176 (41.9)1.19 (0.88-1.61)
        NN46 (12.4)58 (13.8)0.96 (0.61-1.50)
ERCC2 K751Q (A > C)
    KK142 (38.3)159 (37.9)Reference
    KQ/QQ229 (61.7)261 (62.1)0.96 (0.72-1.28)
        KQ181 (48.8)197 (46.9)1.01 (0.74-1.37)
        QQ48 (12.9)64 (15.2)0.81 (0.52-1.25)
ERCC2 C22541A
    CC117 (31.5)137 (32.6)Reference
    CA/AA254 (68.4)283 (67.4)1.06 (0.78-1.43)
        CA188 (50.7)207 (49.3)1.06 (0.77-1.46)
        AA66 (17.8)76 (18.1)1.03 (0.68-1.56)
ERCC4 R415Q (G > A)
    RR316 (85.2)369 (87.9)Reference
    RQ/QQ55 (14.8)51 (12.1)1.23 (0.82-1.86)
        RQ54 (14.6)49 (11.7)1.27 (0.83-1.92)
        QQ1 (0.3)2 (0.5)0.48 (0.04-5.43)
ERCC4 T30028C
    TT186 (50.1)214 (51.0)Reference
    TC/CC185 (49.9)206 (49.0)1.01 (0.76-1.34)
        TC160 (43.1)171 (40.7)1.05 (0.78-1.41)
        CC25 (6.7)35 (8.3)0.84 (0.48-1.47)
ERCC5 D1104H (G > C)
    DD215 (58.0)250 (59.5)Reference
    DH/HH156 (42.0)170 (40.5)1.07 (0.80-1.42)
        DH134 (36.1)148 (35.2)1.07 (0.79-1.43)
        HH22 (5.9)22 (5.2)1.06 (0.56-2.00)
XPA G23A
    GG195 (52.6)185 (44.0)Reference
    GA/AA176 (47.4)235 (56.0)0.70 (0.53-0.93)
        GA147 (39.6)191 (45.5)0.72 (0.54-0.97)
        AA29 (7.8)44 (10.5)0.62 (0.37-1.04)
XPC A499V (C > T)
    AA211 (56.9)213 (50.7)Reference
    AV/VV160 (43.1)207 (49.3)0.79 (0.59-1.05)
        AV129 (34.8)166 (39.5)0.80 (0.59-1.08)
        VV31 (8.4)41 (9.8)0.76 (0.46-1.28)
XPC K939Q (A > C)
    KK153 (41.2)164 (39.0)Reference
    KQ/QQ218 (58.8)256 (61.0)0.89 (0.67-1.19)
        KQ153 (41.2)198 (47.1)0.81 (0.60-1.11)
        QQ65 (17.5)58 (13.8)1.17 (0.76-1.78)
  • * Adjusted for age at reference date (50-54, 55-59, 60-64, and 65-69 y) and county of residence (King, Pierce, and Snohomish).