Table 2.

T tests of GnT-V substrate proteins, LPHA, and traditional breast cancer markers

MarkerLPHA
Matriptase
EGFR
Lamp-1
β1-Integrin
N-Cadherin
ΔPΔPΔPΔPΔPΔP
Node positive↓ 40.8015↑ 560.055↑ 270.1438156<0.0001↑ 550.0488↑ 310.0939
Size > 2 cm↑ 70.6526860.0033↑ 320.08141130.0026↓ 310.2281380.0451
High nuclear grade↑ 70.7043156<0.0001↑ 10.9502↓ 100.8170↓ 280.3857680.0009
HER2 3+↑ 420.11351810.0001↓ 340.2484↓ 210.72191470.0001↑ 380.2045
Estrogen receptor negative↓ 10.9324700.0180↓ 290.1206↓ 40.9222↓ 240.4032↑ 260.1562
Age > 50 y↑ 60.7284↓ 290.3808↑ 50.7987↑ 580.1546↑ 340.2716↓ 80.6952
Lobular↓ 400.1417182<0.0001720.0145↓ 930.1417↓ 580.1818670.0217
  • NOTE: Δ represents the mean difference between tumors fulfilling the traditional marker phenotype (left column) and those that do not (e.g., node-positive tumors have a lamp-1 AQUA score that is 156 points higher than node-negative tumors; P < 0.0001). Statistically significant values are in boldface.