Table 3.

Risk of colorectal cancer by site within quartiles or tertiles of plasma 25(OH)D, among women in the NHS, 1989–2000

Colon
Proximal colon
Distal colon
QuartileCases/controls*OR (95% CI)TertileCases/controls*OR (95% CI)TertileCases/controls*OR (95% CI)
149/751.00133/491.00124/411.00
243/711.03 (0.56–1.89)221/540.62 (0.28–1.37)220/390.68 (0.27–1.74)
327/770.54 (0.28–1.03)324/521.05 (0.43–2.56)317/400.56 (0.19–1.67)
430/720.70 (0.35–1.38)
P for trend0.170.810.35
Rectum
Distal colon + rectum
Tertile
Cases/controls*
OR (95% CI)
Quartile
Cases/controls*
OR (95% CI)
124/311.00136/531.00
210/260.52 (0.14–1.93)230/500.82 (0.38–01.78)
310/310.31 (0.08–1.31)318/520.42 (0.19–0.91)
421/530.46 (0.19–1.09)
P for trend0.030.02
  • * No. cases/controls per quartile or tertile. Controls were matched to cases on year of birth and month of blood draw.

  • ORs and 95% CIs from conditional logistic regression analyses with adjustment for the covariates listed in Table 2 (footnote §).

  • P in test of linear trend in risk over continuous values of 25(OH)D.