Table 1

CHEK2 polymorphism genotype frequencies and genotypic specific risks

PolymorphismSeriesRare allele frequencyCommon homozygote (n)Heterozygote (n)Rare homozygote (n)χ2 (P) Incident versus prevalent casesχ2 (P) cases versus controls
IVS1 + 38insaIncident cases0.1571328215
(5a/6a)Prevalent cases0.16431161152.3 (0.3)2.6 (0.3)
Controls0.17106643141
OR1.00.960.68
95% CI0.82–1.10.42–1.1
95% FCI0.92–1.10.84–1.10.43–1.1
a1013gIncident cases0.0241001481
Prevalent cases0.0266983420.8 (0.7)3.9 (0.2)a
Controls0.0181763641
OR1.01.3b3.1
95% CI0.96–1.90.28–30
95% FCIc0.93–1.10.96–1.90.28–30
  • a Fisher’s exact test, P = 0.17.

  • b P = 0.09.

  • a FCI = floated confidence interval (see text for explanation).