Table 2

ORa and 95% CI of colorectal cancer according to fourths of markersb of insulin and glucose control, CLUE II cohort of Washington County, Maryland, 1989–2000

MarkerFourthscPtrend
1234
Insulin
 Cases/controls43/8453/8642/8934/85
 ORa1.001.200.920.780.24
 (95% CI)Reference(0.72–2.00)(0.55–1.53)(0.45–1.35)
Ratio of total cholesterol:HDL-cholesterol
 Cases/controls48/8244/8243/8335/82
 ORa1.000.940.890.740.28
 (95% CI)Reference(0.54–1.65)(0.53–1.50)(0.42–1.29)
Triglycerides
 Cases/controls53/8238/8242/8637/84
 ORa1.000.730.720.690.17
 (95% CI)Reference(0.43–1.23)(0.42–1.24)(0.41–1.16)
IGFBP-1
 Cases/controls46/8246/8433/8644/83
 ORa1.000.970.680.930.53
 (95% CI)Reference(0.57–1.66)(0.39–1.18)(0.55–1.58)
HbA1c
 Cases/controls39/8729/8643/8662/87
 ORa1.000.771.121.570.02
 (95% CI)Reference(0.43–1.36)(0.65–1.91)(0.94–2.60)
  • a ORs estimated from conditional logistic regression. Cases and controls were matched on age, sex, race, time since last meal, and date of blood draw.

  • b Measurements were unavailable for some participants because of insufficient plasma volume. Included in the analysis were sets for which the case and at least one control had information available. The counts are insulin 172 cases, 344 controls; ratio of cholesterol: HDL-cholesterol 170 cases and 329 controls; triglycerides 170 cases, 334 controls; and IGFBP-1 169 cases, 335 controls.

  • c Cut points based on the distribution of concentrations among the controls. For insulin, triglycerides, and IGFBP-1 cut points for the fourths of the distribution of concentrations among the controls were determined separately within strata of time since last meal. The quartile cut points were as follows: insulin (milliunits/liter): 0–1 h: 21.19, 33.01, 49.71; 2–3 h: 6.36, 16.41, 29.48; 4–5 h: 4.92, 8.24, 18.86; 6–7 h: 3.89, 8.14, 12.20; 8+ h: 4.94, 8.15, 17.36. Ratio of total cholesterol (mg/dl): HDL cholesterol (mg/dl): 4.04, 5.07, 6.20; triglycerides (mg/dl): 0–1 h: 121.5, 170.5, 226.5; 2–3 h: 122.5, 165.5, 218.5; 4–5 h: 105, 144.5, 230; 6–7 h: 87.5, 129.0, 219.5; 8+ h: 94, 131, 182.5. IGFBP-1 (ng/ml): 0–1 h: 7.12, 19.64, 47.28; 2–3 h: 4.10, 10.92, 21.71; 4–5 h: 2.75, 14.97, 35.15; 6–7 h: 5.38, 43.16, 88.74; 8+ h: 10.85, 30.09, 60.23; HbA1c (%): 5.38, 5.54, 5.78.