Table 1

Frequency of PI3K-p85 genotype, age and smoking-adjusted OR and 95% CI of CaP in the Physicians’ Health Study

PI3K-p85 genotype
Met/MetMet/IleIle/IleMet/Ile and Ile/Ile
Controls (%)495 (67.1)230 (31.2)13 (1.8)243 (32.9)
Overall cases (%)378 (68.1)166 (29.9)11 (2.0)177 (31.9)
OR (95% CI)1.00 (reference)0.95 (0.74–1.20)1.11 (0.49–2.50)0.95 (0.75–1.21)
Low-grade/stage cases (%)176 (65.7)85 (31.7)7 (2.6)92 (34.3)
OR (95% CI)1.00 (reference)1.04 (0.77–1.40)1.52 (0.59–3.87)1.06 (0.79–1.43)
High-grade/stage cases (%)183 (71.2)71 (27.6)3 (1.2)74 (28.8)
OR (95% CI)1.00 (reference)0.84 (0.61–1.15)0.61 (0.17–2.17)0.82 (0.60–1.12)
Death caused by CaP52 (72.2)19 (26.4)1 (1.4)20 (27.8)
OR (95% CI)1.00 (reference)0.80 (0.46–1.38)0.72 (0.09–5.69)0.79 (0.46–1.36)