Table 5

Frequency distribution of genotypes by ethnic background

CovariateEthnic backgroundP
CaucasianBlackAsian
SRD5A2
VV433 (50.1%)54 (60.0%)13 (22.0%)
V/L371 (42.9%)29 (32.2%)25 (42.4%)0.0001
L/L61 (7.0%)7 (7.8%)21 (35.6%)
Androgen receptor
 >18 CAG repeats768 (88.8%)58 (64.4%)55 (93.2%)0.0001
 ≤18 CAG repeats97 (11.2%)32 (35.6%)4 (6.8%)
CYP17
A1/A1316 (36.5%)32 (35.6%)18 (30.5%)
A1/A2412 (47.6%)38 (42.2%)26 (44.1%)0.22
A2/A2137 (15.9%)20 (22.2%)15 (25.4%)
CYP3A4
WW792 (91.5%)14 (15.6%)57 (96.6%)
WV67 (7.8%)37 (41.1%)2 (3.4%)0.0001
VV6 (0.7%)39 (43.3%)0 (0%)
PSA
AA279 (32.3%)32 (35.6%)9 (15.3%)
AG375 (43.3%)44 (48.9%)18 (30.5%)0.0001
GG211 (24.4%)14 (15.5%)32 (54.2%)
VDR
bb221 (25.5%)12 (13.3%)5 (8.5%)
Bb317 (36.7%)42 (46.7%)11 (18.6%)0.0001
BB327 (37.8%)36 (40.0%)43 (72.9%)
GST-T1
 0164 (19.0%)30 (33.3%)18 (30.5%)0.001
 1701 (81.0%)60 (66.7%)41 (69.5%)
GST-M1
 0432 (49.9%)25 (27.8%)36 (61.0%)0.0001
 1433 (50.1%)65 (72.2%)23 (39.0%)
GST-P1
IL/IL439 (50.7%)29 (32.2%)35 (59.3%)
IL/V375 (43.4%)52 (57.8%)24 (40.7%)0.002
VV51 (5.9%)9 (10.0%)0 (0%)
IGF-I
No 19 allele106 (12.3%)43 (47.8%)16 (27.1%)0.0001
One 19 allele407 (47.0%)38 (42.2%)32 (54.2%)
Two 19 alleles352 (40.7%)9 (10.0%)11 (18.7%)
IGFBP-3
AA251 (29.0%)15 (16.7%)9 (15.3%)
AC433 (50.1%)44 (48.9%)24 (40.7%)0.0001
CC181 (20.9%)31 (34.4%)26 (44.0%)