Table 2

Frequency of alcohol flushing in 233 cases and 610 control subjects, by ALDH2 and ADH2 genotypes

GenotypeCasesControls
NCurrent flushingaFormer flushingaNever flushingaNCurrent flushingaFormer flushingaNever flushinga
ALDH2
2*1/2*16211.3%6.5%82.3%3264.9%7.1%88.0%
2*1/2*216956.2%28.4%15.4%24270.3%18.6%11.2%
2*2/2*22100.0%0.0%0.0%4297.6%0.0%2.4%
Pb<0.0001<0.0001
ADH2
2*1/2*15133.3%23.5%43.1%3129.0%22.6%48.4%
2*1/2*27343.8%27.4%28.8%21234.4%7.1%58.5%
2*2/2*210950.5%18.4%31.2%36739.5%12.5%48.0%
Pb0.170.018
  • a See text for definitions of flushing status (“Questionnaires”).

  • b Fisher’s exact test.