Table 3

Total plasma genistein pharmacokinetic parameters after dosing with 90% genistein (means ± SD)

Subject no.Tablets takenDose level (mg/kg)Tmaxab (h)Cmaxm)AUC0-∞m·h)Apparent T1/2c (h)CL/F (liters/h)VZ/F (liters)MRT (h)
1126.0 (3–8)5.02 (1.58)92.2 (32.3)15.53 (2.37)6.28 (2.00)138.7 (31.0)22.06 (2.32)
21
31
41
5344.5 (3–8)12.18 (9.42)205.7 (206.6)29.48 (26.76)5.63 (1.76)341.4 (229.9)58.21 (30.72)
63
72
8483.0 (2–24)4.34 (1.88)112.0 (96.6)30.45 (11.83)30.04 (22.30)1403.2 (1031.3)45.67 (21.3)
95
104
115
Totals4.5 (2–24)22.41 (10.40)14.75 (17.38)653.8 (830.6)40.52 (23.82)
  • a Tmax, time of maximal plasma concentration; Cmax, maximal plasma concentration; AUC0-∞, area under the concentration-time curve extrapolated to infinity; CL/F, apparent clearance; T1/2, apparent terminal half-life of elimination; VZ/F, apparent volume of distribution during the terminal elimination phase.

  • b Median and range.

  • c Harmonic means and pseudostandard deviations.