Table 4

Segregation analysis of 231 families of noncarrier cases: α-specific models

ParameterNon-mendelianMendelian
SporadicEnvironmentalArbitraryCodominantDominantRecessiveGeneral modelRecessive free tAB
qA1.0a0.9390.7940.2450.01060.1990.201
τAA0.939a1.0a1.0a1.0a1.0a0.921.0a
τAB0.939a0.5a0.5a0.5a0.5a0.090.51
τBB0.939a0.0a0.0a0.0a0.0a1.0b0.0a
βAA−8.2−9.0
βAB−12.7a−14.5
βBB−17.2−11.12
β men−50.0a−50.0a−50.0a−50.0a−50.0a−50.0a−50.0a
β women−6.87−9.62−8.88−8.34−8.87−8.87
αAAc0.08580.1030.09330.15170.1600.1670.161
αABc0.1830.09320.1517a0.093a0.0990.093a
αBBc0.1500.160.09020.0930.0210.093
α men0.02a0.02a0.02a0.02a0.02a0.02a0.02a0.02a
α women0.137
γc0.540.8850.910.780.580.940.490.92
−2lnL983.15970.93971.18970.89972.12968.68958.28968.8
χ228.5712.6512.912.6113.8410.410.52
AICd986.15984.93983.68980.89982.12978.68
Degrees of freedom376555126
p0.0010.030.0440.080.0540.170.10
Type frequency; mean age of onset
 Type AA1; 800.34; 890.63; 950.06; 590.092; 610.04; 550.04; 55
 Type AB00.49; 1000.32; 950.37; 910.96; 950.96; 95
 Type BB00.17; 570.04; 550.56; 1240.90; 87
  • a Parameter value fixed in analysis.

  • b Parameter hit bound.

  • c Female-specific.

  • d AIC, Akaike information criterion.