Table 4

Total cancer incidence by treatment group and subgroups defined by baseline characteristics

CasesUnadjustedaAdjustedb
SePlaceboRR95% CIPP, M-HHR95% CIPP, intc
Age (yrs)
 ≤6546640.750.50–1.110.130.950.760.52–1.12d0.170.98
 >6559730.740.51–1.050.080.750.54–1.07d0.11
Gender
 Female23201.140.60–2.200.660.131.200.66–2.20e0.550.14
 Male821170.680.51–0.920.0080.670.50–0.89e0.005
Smoking status
 Never25260.850.47–1.530.570.650.810.47–1.41f0.460.76
 Former42610.670.44–1.010.050.660.44–0.97f0.04
 Current38500.860.55–1.330.470.860.56–1.31f0.47
  • a RR and 95% CI were derived from incidence rate ratios; Ps were derived from log-rank (P) test and Mantel-Haenszel (P, M-H) test for heterogeneity.

  • b HR, 95% CI, and Ps from the Cox proportional hazards model:

  • d , adjusted for gender and smoking status (never, former, current) at baseline;

  • e , adjusted for age (continuous) and smoking status (never, former, current) at baseline; and

  • f , adjusted for age (continuous) and gender at baseline.

  • c Ps for treatment group characteristic interaction is for the (treatment group × factor) cross-product term in separate Cox proportional hazards models.