Table 1

Log-likelihood ratio tests for nested models describing variation of BRCA1 cancer risks with mutation position

Likelihood maximized using all 356 families carrying PT BRCA1 mutations. RR (Γ) in italics are those fixed at one under the given model; other entries are the maximum likelihood estimates under the given model. Model 4 (bold text) provides the most parsimonious fit to the data.

ModelBreast RR (Γb)Ovarian RR (Γv)Log-likelihoodLikelihood ratio statisticP
Centre [Γb(c)]3 [Γb(3)]Center [Γo(c)]3 [Γo(3)]
1 (null) 1 1 1 1 −1324.4271
20.69 1 1 1 −1315.528817.7970.00002 vs. model 1
3 1 1 1 0.76−1320.61707.6200.006 vs. model 1
4 0.71 1 1 0.81 −1313.5064 4.0450.044 vs. model 2
14.2210.0002 vs. model 3
50.771.11 1 0.84−1312.85881.2950.26 vs. model 4
60.72 1 1.060.83−1313.38700.2390.63 vs. model 4
Full0.761.121.100.88−1312.5896