Table 2

Adjusted mean hormone concentrations (nmol/liter) by time of day and time since last meal at venipuncture, days between venipuncture, and blood processinga

VariableNos.IGF-IIGFBP-1IGFBP-2IGFBP-3C-peptideSHBG
Time of day at venipuncture
 <9.307231.4 (29.3–33.6)1.25 (1.03–1.51)11.8 (10.1–13.7)153 (146–160)0.82 (0.73–0.91)47.7 (42.1–53.8)
 9.30–10.447429.0 (27.2–30.9)1.13 (0.94–1.35)13.6 (11.9–15.4)142 (136–149)0.83 (0.75–0.92)50.7 (45.1–56.9)
 10.45–13.297229.3 (27.4–31.3)1.01 (0.84–1.22)14.5 (12.6–16.4)144 (137–151)0.72 (0.64–0.80)51.4 (45.6–57.9)
 13.30+7429.4 (27.5–31.4)0.74 (0.61–0.89)13.3 (11.6–15.2)137 (131–144)0.93 (0.84–1.03)60.6 (52.7–68.3)
 Heterogeneity/linear0.382/0.2470.0001/0.00010.158/0.4160.032/0.0160.005/0.1540.108/0.022
Time since last meal at venipuncture (hrs·min)
 <1.157329.0 (27.2–30.9)1.25 (1.04–1.50)12.4 (10.8–14.2)145 (139–152)1.12 (1.02–1.23)53.2 (47.3–59.8)
 1.15–1.597630.9 (29.0–33.0)0.89 (0.75–1.07)12.6 (11.0–14.4)142 (136–149)0.93 (0.84–1.02)48.5 (43.2–54.4)
 2.00–3.296930.6 (28.6–32.8)0.71 (0.59–0.86)14.6 (12.7–16.6)147 (140–154)0.75 (0.67–0.84)51.4 (45.4–58.2)
 3.30+7428.5 (26.7–30.4)1.32 (1.10–1.58)13.7 (11.9–15.5)142 (135–148)0.55 (0.48–0.62)56.7 (50.5–64.8)
 Heterogeneity/linear0.305/0.5430.0001/0.8010.158/0.2120.642/0.5680.0001/0.00010.310/0.357
Time between venipuncture and blood processing (days)
 116429.9 (28.7–31.2)1.04 (0.92–1.17)13.6 (12.4–14.8)143 (139–147)0.95 (0.89–1.00)52.5 (48.6–56.8)
 27929.4 (27.6–31.3)0.95 (0.80–1.14)12.7 (11.1–14.5)143 (138–151)0.75 (0.67–0.84)51.1 (45.6–57.3)
 32929.8 (26.9–33.2)1.05 (0.78–1.41)13.1 (10.3–16.1)148 (138–160)0.60 (0.49–0.73)52.3 (43.0–63.5)
 4+2029.4 (26.0–33.3)1.00 (0.71–1.42)13.6 (10.4–17.2)145 (133–158)0.52 (0.40–0.66)55.5 (44.4–69.4)
 Heterogeneity/linear0.957/0.6890.948/0.6510.957/0.6120.832/0.5430.0001/0.00010.978/0.917
  • a Values are adjusted for each other and age group (10 categories), BMI group (4 categories), diet group (3 categories), and assay batch (4 categories).