Table 3

RR of breast cancer in women according to adult weight change: NHEFS

Adult weight change (kg)Person-years of observationNo. of casesMultivariate-adjusted RR (95% CI)a
All women
 Lost 5.0+2,589122.91 (1.41–5.99)
 Lost/gained 4.914,320281 (referent)
 Gained 5.0–9.99,662201.00 (0.56–1.77)
 Gained 10.0–19.913,193421.53 (0.94–2.48)
 Gained 20+9,253331.72 (0.94–2.89)
P for trendb 0.275/0.015
Women <50 yrs of age
 Lost 5.0+89911.63 (0.20–13.38)
 Lost/gained 4.97,544121.0
 Gained 5.0–9.94,87870.87 (0.34–2.21)
 Gained 10.0–19.95,409131.62 (0.72–3.60)
 Gained 20+3,42881.88 (0.73–4.88)
P for trendb 0.151/0.116
Women ≥50 yrs of age
 Lost 5.0+1,690113.26 (1.44–7.38)
 Lost/gained 4.96,776161.0
 Gained 5.0–9.94,784131.08 (0.52–2.26)
 Gained 10.0–19.97,784291.56 (0.84–2.90)
 Gained 20+5,824251.74 (0.91–3.30)
P for trendb 0.568/0.054
  • a Models were adjusted for height, BMI at age 25 years, physical activity in 1982–1984 + 1971–1975, and sample design variables.

  • b Tests of trend were performed including/excluding women who lost ≥5 kg.