Table 4

Significant correlations between the blood levels of SAM, SAH, and SAM:SAH ratios and homocysteine versus the dietary levels of folate and vitamin B6 during the preliminary (Usual) and the experimental (Exp) portions of the studya

Blood parameter and vitaminaPeriodSexnrP
HCys
 B6UsualbM33−0.522<0.01
M + F66−0.377<0.01
 B6cExpbM33−0.352<0.05
M + F66−0.254<0.05
 FolateUsualM33−0.508<0.01
M + F66−0.431<0.01
SAM
 B6ExpM + F (Unadjusted)660.438<0.01
 FolateExpM + F (Unadjusted)660.386<0.01
SAM/SAH
 B6ExpM + F (Unadjusted)660.271<0.05
 FolateExpM + F (Unadjusted)660.303<0.05
  • a Unless otherwise specified, the correlations were calculated on the basis of total daily intake of each vitamin.

  • b For the Usual portion of the study, the blood levels of the methyl intermediates at day 0 were compared with the vitamin intakes during this period; in the Exp portion of the study, the levels of the methyl intermediates at days 7 and 14 were averaged for corresponding regression analysis.

  • c Intake is calculated as mg/kg/day.