Table 3

Comparison of molecular factors in tissue from breasts with low and high breast density in women < and ≥ 50 years of age

Low densityaHigh densityaDifference (low-high)bPc
A. Women <50 years of age; n = 24 pairs; mean age = 44 years
Percentage of nuclear area0.07a (0.84)1.23 (0.80)−1.17 (1.16)0.0001
Percentage of total collagen (n = 22)1.76 (1.86)3.17 (1.83)−1.41 (2.64)0.02
Percentage of IGF-1−0.42 (1.42)0.89 (1.05)−1.31 (1.69)0.0009
Percentage of TGF-α−1.53 (1.81)−1.34 (2.49)−0.19 (2.95)0.75
Percentage of TIMP-3−1.54 (2.21)0.52 (2.22)−2.06 (3.17)0.004
B. Women ≥50 years of age; n = 22 age matched pairs; mean age = 57 years
Percentage of nuclear area0.49 (0.91)0.42 (0.85)0.07 (1.36)0.82
Percentage of total collagen (n = 19)2.80 (1.24)3.32 (0.96)−0.76 (1.77)0.08
Percentage of IGF-1 (n = 21)−0.14 (2.22)0.02 (1.57)−0.16 (2.48)0.78
Percentage of TGF-α (n = 21)−1.17 (2.32)−1.65 (1.95)0.49 (2.81)0.44
Percentage of TIMP-3−0.38 (2.65)−0.83 (2.63)0.45 (2.90)0.48
  • a Results expressed as mean (SD) of log-transformed values.

  • b Paired difference (low-high density log-transformed value) expressed as mean (SD).

  • c P for t test for paired difference.