Table 2

Comparison of molecular factors in tissue from breasts with low density and high density (n = 46 age matched pairs)

Low densityaHigh densityaDifference (low-high)bPc
Percentage of nuclear area (n = 46)0.27a (0.89)0.85 (0.91)−0.58 (1.40)0.007
Percentage of total collagend (n = 41)2.21 (1.66)3.32 (1.56)−1.11 (2.27)0.003
Percentage of IGF-1e (n = 45)−0.29 (1.82)0.48 (1.37)−0.77 (2.15)0.02
Percentage of TGF-αe (n = 45)−1.36 (2.05)−1.49 (2.24)0.12 (2.87)0.77
Percentage of TIMP-3 (n = 46)−0.99 (2.47)−0.12 (2.49)−0.86 (3.27)0.08
  • a Results expressed as mean (SD) of log-transformed values.

  • b Paired differences (low-high density log-transformed value) expressed as mean (SD).

  • c P for t-test for paired difference.

  • d Values missing because of sections unsuitable for staining (n = 2) and staining measurement problems (n = 2).

  • e Value missing because of sections unsuitable for staining (n = 1 for each measure).