Table 2

Distribution of bladder cancer cases and controls by NAT2 genotype, smoking habits, and other characteristics. Caucasians only. ORs adjusted by age, gender, and study (Mantel-Haenszel estimates). 95% CIs (studies: Refs. 13 14 15 16 )

CasesControlsOR95% CI
Gender
 Women3062751.0
 Men7224561.331.05–1.68
Age <55901561.0
 55–641952051.491.06–2.09
 65–743592232.531.86–3.45
 75–79204963.552.42–5.20
 80+179516.164.10–9.26
NAT2
 Rapid3272771.0
 Slow6564021.421.14–1.77
Breslow-Day test for homogeneity of ORs across studies 7.99 (P = 0.046)
 Smoking habits
  Never smokers2192091.0
  Ever smokers8045131.691.33–2.14
  Known ex-smokers118722.801.70–4.60
  Known current smokers2442046.053.82–9.57
Breslow-Day test for homogeneity of ORs across studies 47.45 (P = 0.001)
 Occupational exposures
  No4004081.0
  Yes3311302.241.70–2.94
Breslow-Day test for homogeneity of ORs across studies 1.21 (P = 0.271)