Background: Recent data showed that melanoma was more common among patients with Parkinson's disease (PD) than individuals without PD and vice versa. It has been hypothesized that these two diseases may share common genetic and environmental risk factors. Methods: We evaluated the association between single-nucleotide polymorphisms (SNPs) selected based on recent genome-wide association studies (GWAS) on PD risk and the risk of melanoma using 2,297 melanoma cases and 6,651 controls. Results: The PD SNP rs156429 in the chromosome 7p15 region was nominally associated with melanoma risk with p-value of 0.04, which was not significant after the Bonferroni correction for multiple comparisons. No association was observed between the remaining 31 PD SNPs and the risk of melanoma. The genetic score based on the number of PD risk allele was not associated with melanoma risk (odds ratio for the highest genetic score quartile (30-35) vs. the lowest (15-20), 1.13, 95% confidence interval, 0.47-2.70). Conclusions: The PD SNPs identified in published GWAS do not appear to play an important role in melanoma development. Impact: The PD susceptibility loci discovered by GWAS contribute little to the observed epidemiological association between the PD and melanoma.
- Received October 5, 2011.
- Accepted November 3, 2011.
- Copyright © 2011, American Association for Cancer Research.