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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention

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Research Articles

The Influence of Prediagnosis Alcohol Consumption and the Polymorphisms of Ethanol-Metabolizing Genes on the Survival of Head and Neck Cancer Patients

Wei-Ting Lee, Jenn-Ren Hsiao, Chun-Yen Ou, Cheng-Chih Huang, Chan-Chi Chang, Sen-Tien Tsai, Ken-Chung Chen, Jehn-Shyun Huang, Tung-Yiu Wong, Yu-Hsuan Lai, Yuan-Hua Wu, Wei-Ting Hsueh, Shang-Yin Wu, Chia-Jui Yen, Jang-Yang Chang, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen and Jeffrey S. Chang
Wei-Ting Lee
Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Jenn-Ren Hsiao
Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Chun-Yen Ou
Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Cheng-Chih Huang
Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Chan-Chi Chang
Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Sen-Tien Tsai
Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Ken-Chung Chen
Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Jehn-Shyun Huang
Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Tung-Yiu Wong
Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Yu-Hsuan Lai
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Yuan-Hua Wu
Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Wei-Ting Hsueh
Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Shang-Yin Wu
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Chia-Jui Yen
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Jang-Yang Chang
Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
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Chen-Lin Lin
Department of Nursing, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Ya-Ling Weng
National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
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Han-Chien Yang
National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
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Yu-Shan Chen
Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
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Jeffrey S. Chang
National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
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  • For correspondence: jeffreychang@nhri.org.tw
DOI: 10.1158/1055-9965.EPI-18-0425 Published February 2019
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Abstract

Background: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pretreatment alcohol consumption and the overall survival (OS) of HNC patients.

Methods: Cox proportional hazards models were performed to evaluate the association between prediagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on this relationship was also evaluated.

Results: The results showed a significant positive dose–response relationship between prediagnosis alcohol use and worse OS of HNC patients. This association was more significant for oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer than for oral cancer. The association between alcohol use and the poorer OS of HNC patients was mainly through its association with a higher stage of HNC at diagnosis. The worst OS associated with alcohol use was observed among HNC patients with the fast ADH1B and the slow/nonfunctional ALDH2 genotype combination.

Conclusions: Our analysis showed a significant positive dose–response relationship between prediagnosis alcohol use and a worse OS of HNC. This association was mainly due to the higher stage of HNC among alcohol drinkers. In addition, the polymorphisms of the ethanol-metabolizing genes, ADH1B and ALDH2, modified the relationship between prediagnosis alcohol use and the OS of HNC patients.

Impact: Prediagnosis alcohol use may be a prognostic indicator of HNC.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Epidemiology, Biomarkers & Prevention Online (http://cebp.aacrjournals.org/).

  • Received April 17, 2018.
  • Revision received July 17, 2018.
  • Accepted September 24, 2018.
  • Published first October 1, 2018.
  • ©2018 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 28 (2)
February 2019
Volume 28, Issue 2
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The Influence of Prediagnosis Alcohol Consumption and the Polymorphisms of Ethanol-Metabolizing Genes on the Survival of Head and Neck Cancer Patients
Wei-Ting Lee, Jenn-Ren Hsiao, Chun-Yen Ou, Cheng-Chih Huang, Chan-Chi Chang, Sen-Tien Tsai, Ken-Chung Chen, Jehn-Shyun Huang, Tung-Yiu Wong, Yu-Hsuan Lai, Yuan-Hua Wu, Wei-Ting Hsueh, Shang-Yin Wu, Chia-Jui Yen, Jang-Yang Chang, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen and Jeffrey S. Chang
Cancer Epidemiol Biomarkers Prev February 1 2019 (28) (2) 248-257; DOI: 10.1158/1055-9965.EPI-18-0425

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The Influence of Prediagnosis Alcohol Consumption and the Polymorphisms of Ethanol-Metabolizing Genes on the Survival of Head and Neck Cancer Patients
Wei-Ting Lee, Jenn-Ren Hsiao, Chun-Yen Ou, Cheng-Chih Huang, Chan-Chi Chang, Sen-Tien Tsai, Ken-Chung Chen, Jehn-Shyun Huang, Tung-Yiu Wong, Yu-Hsuan Lai, Yuan-Hua Wu, Wei-Ting Hsueh, Shang-Yin Wu, Chia-Jui Yen, Jang-Yang Chang, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen and Jeffrey S. Chang
Cancer Epidemiol Biomarkers Prev February 1 2019 (28) (2) 248-257; DOI: 10.1158/1055-9965.EPI-18-0425
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