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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention

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The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies

Xia Zhang, Qian Zhao, Wei Zhu, Tao Liu, Shao-Hua Xie, Li-Xin Zhong, Yuan-Yuan Cai, Xiao-Na Li, Mei Liang, Wen Chen, Qian-Sheng Hu and Bo Zhang
Xia Zhang
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
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Qian Zhao
School of Public Health, Guangzhou Medical University, Guangzhou, China.
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Wei Zhu
Department of Toxicology, Guangzhou Centre for Disease Control and Prevention, Guangzhou, China.
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Tao Liu
Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
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Shao-Hua Xie
Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
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Li-Xin Zhong
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
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Yuan-Yuan Cai
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
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Xiao-Na Li
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
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Mei Liang
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
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Wen Chen
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
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Qian-Sheng Hu
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
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Bo Zhang
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
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  • For correspondence: zhangb65@mail.sysu.edu.cn
DOI: 10.1158/1055-9965.EPI-16-0968 Published September 2017
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Abstract

The association between telomere length (TL) in peripheral blood cells and cancer risk remains inconclusive. We carried out a meta-analysis on prospective studies. The study-specific RR estimates were first transformed to a common comparable scale and then were pooled by a random-effects model. The dataset was composed of 13,894 cases and 71,672 controls from 28 studies in 25 articles. In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% confidence interval (CI), 0.952–1.238]. Subgroup analyses showed that the association was stronger in lung cancer (n = 3; OR = 1.690; 95% CI, 1.253–2.280), in men (n = 6; OR = 1.302; 95% CI, 1.120–1.514) and in studies with more precise methods for DNA extraction (phenol–chloroform, salting-out or magnetic bead, n = 6, OR = 1.618; 95% CI, 1.320–1.985) and TL measurement (multiplex Q-PCR, n = 8; OR = 1.439; 95% CI, 1.118–1.852). Our meta-analysis suggested longer TL in peripheral blood cells is a likely risk factor for lung cancer or cancers in men. Accurate DNA extraction and TL measurement methods make it more liable to find significant associations between TL and cancer risk and thus should be taken into consideration in future epidemiologic studies. Cancer Epidemiol Biomarkers Prev; 26(9); 1381–90. ©2017 AACR.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Epidemiology, Biomarkers & Prevention Online (http://cebp.aacrjournals.org/).

  • Received December 1, 2016.
  • Revision received April 27, 2017.
  • Accepted June 5, 2017.
  • ©2017 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 26 (9)
September 2017
Volume 26, Issue 9
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The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies
Xia Zhang, Qian Zhao, Wei Zhu, Tao Liu, Shao-Hua Xie, Li-Xin Zhong, Yuan-Yuan Cai, Xiao-Na Li, Mei Liang, Wen Chen, Qian-Sheng Hu and Bo Zhang
Cancer Epidemiol Biomarkers Prev September 1 2017 (26) (9) 1381-1390; DOI: 10.1158/1055-9965.EPI-16-0968

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The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies
Xia Zhang, Qian Zhao, Wei Zhu, Tao Liu, Shao-Hua Xie, Li-Xin Zhong, Yuan-Yuan Cai, Xiao-Na Li, Mei Liang, Wen Chen, Qian-Sheng Hu and Bo Zhang
Cancer Epidemiol Biomarkers Prev September 1 2017 (26) (9) 1381-1390; DOI: 10.1158/1055-9965.EPI-16-0968
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