Apoptosis in the Colonic Crypt, Colorectal Adenomata, and Manipulation by Chemoprevention
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Nicholas J. West, Endoscopy Department, St George's Hospital, Blackshaw Road, London, SW17 OQT, UK. Phone: 44-020-8725-5789; Fax: 44-020-8725-3284. E-mail: njw{at}medix-uk.com
Abstract
This review discusses the biology and the methods of assessment of apoptosis, of which, the monoclonal antibody M30 would seem to be the most useful; the role of apoptosis in the etiology of colorectal cancer; and its use as a marker to monitor the beneficial effects of chemopreventative interventions to reduce the development of colorectal cancer within the context of clinical trials. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1680–7)
Footnotes
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↵1 Cancer Research UK [homepage on the Internet]. London: Cancer Research UK [cited 2007 October 15]. Cancer Worldwide. Available from: http://info.cancerresearchuk.org/cancerstats/geographic/world/commoncancers/#source1.
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- Accepted March 31, 2009.
- Received January 4, 2009.
- Revision received March 9, 2009.
