Article Figures & Data
Figures
- Figure 1.
Distribution of Rasch-modeled nicotine withdrawal sensitivity scores in the SMOFAM sample.
- Figure 2.
Multipoint LOD score (y-axis) for Rasch-modeled nicotine withdrawal sensitivity score by chr6 cM location (x-axis) in the SMOFAM sample. Vertical line at 147.9 cM indicates location of OPRM1 locus.
- Figure 3.
Pairwise linkage disequilibrium among 46 genotyped OPRM1 SNPs in the SMOFAM sample. Within each cell is the pairwise estimation of the correlation coefficient between pairs of SNPs (r2). *, SNPs used in OPRM1 SNP association analyses.
Tables
- Table 1.
Characteristics of subjects with complete genotype and Rasch-modeled nicotine withdrawal score data
n (%) Gender Male 204 (48.7) Female 215 (51.3) Smoker status Experimenter* 9 (2.2) Current† 216 (51.6) Former‡ 194 (46.3) ↵*Experimenter smoker: smoking ≥100 cigarettes in a lifetime and not ever smoking on a daily basis.
↵†Current smoker: ever smoking a cigarette even a puff and smoking ≥100 cigarettes in a lifetime and currently smoking ≥1 cigarettes on most days or currently smoking ≥1 cigarettes on most days and not having quit smoking cigarettes completely.
↵‡Former smoker: ever smoking a cigarette even a puff and ever smoking on a daily basis and quitting smoking cigarettes completely.
- Table 2.
OPRM1 SNPs and association with Rasch-modeled nicotine withdrawal sensitivity
Name Position* Genomic† MAF‡ Chisq Global P FDR Q rs1799971 154452910 Ex1-173 0.13 3.28 0.0702 0.0821 rs477292 154455500 IVS1+2418 0.226 5.73 0.0167 0.0586 rs4870266 154461111 IVS1+8029 0.066 0.018 0.8937 0.5534 rs610231 154470590 IVS1+17508 0.113 2.19 0.1390 0.1463 rs3823010 154471265 IVS1+18183 0.178 4.14 0.0418 0.0599 rs589046 154485251 IVS1-17823 0.261 5.90 0.0152 0.0586 rs563649 154500080 IVS1-2994 0.085 0.39 0.5316 0.5082 rs9322446 154500815 IVS1-2259 0.136 4.79 0.0286 0.0599 rs510587 154505541 IVS3+711 0.054 4.00 0.0455 0.0599 rs9282821 154506488 IVS3-30 0.413 0.13 0.7173 0.5188 rs3798683 154510527 IVS4+3759 0.194 4.29 0.0384 0.0599 rs599548 154510674 IVS4+3906 0.133 <0.01 0.9562 0.5592 rs623956 154522138 IVS4-9792 0.238 0.24 0.6276 0.5082 rs606148 154528099 IVS4-3831 0.099 4.29 0.0383 0.0599 rs1323041 154531293 IVS4-637 0.463 0.07 0.7886 0.5188 rs512053 154531629 IVS4-301 0.08 0.09 0.7679 0.5188 rs10485058 154537327 IVS5+4908 0.121 5.77 0.0164 0.0586 rs613355 154541962 IVS5+9543 0.347 0.24 0.6234 0.5082 ↵*Chromosome positions are based on NCBI Human Genome Assembly, chr6.
↵†Genomic annotation obtained at genewindow.nci.nih.gov.
↵‡Minor allele frequency of the SNP in the SMOFAM sample.
Supplementary Data
Files in this Data Supplement:
Volume 18, Issue 12
