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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention

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Research Articles

Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) Sample

Jill Hardin, Yungang He, Harold S. Javitz, Jennifer Wessel, Ruth E. Krasnow, Elizabeth Tildesley, Hyman Hops, Gary E. Swan and Andrew W. Bergen
Jill Hardin
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Yungang He
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Harold S. Javitz
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Jennifer Wessel
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Ruth E. Krasnow
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Elizabeth Tildesley
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Hyman Hops
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Gary E. Swan
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Andrew W. Bergen
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DOI: 10.1158/1055-9965.EPI-09-0960 Published December 2009
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  • Figure 1.
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    Figure 1.

    Distribution of Rasch-modeled nicotine withdrawal sensitivity scores in the SMOFAM sample.

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    Figure 2.

    Multipoint LOD score (y-axis) for Rasch-modeled nicotine withdrawal sensitivity score by chr6 cM location (x-axis) in the SMOFAM sample. Vertical line at 147.9 cM indicates location of OPRM1 locus.

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    Figure 3.

    Pairwise linkage disequilibrium among 46 genotyped OPRM1 SNPs in the SMOFAM sample. Within each cell is the pairwise estimation of the correlation coefficient between pairs of SNPs (r2). *, SNPs used in OPRM1 SNP association analyses.

Tables

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  • Table 1.

    Characteristics of subjects with complete genotype and Rasch-modeled nicotine withdrawal score data

    n (%)
    Gender
        Male204 (48.7)
        Female215 (51.3)
    Smoker status
        Experimenter*9 (2.2)
        Current†216 (51.6)
        Former‡194 (46.3)
    • ↵*Experimenter smoker: smoking ≥100 cigarettes in a lifetime and not ever smoking on a daily basis.

    • ↵†Current smoker: ever smoking a cigarette even a puff and smoking ≥100 cigarettes in a lifetime and currently smoking ≥1 cigarettes on most days or currently smoking ≥1 cigarettes on most days and not having quit smoking cigarettes completely.

    • ↵‡Former smoker: ever smoking a cigarette even a puff and ever smoking on a daily basis and quitting smoking cigarettes completely.

  • Table 2.

    OPRM1 SNPs and association with Rasch-modeled nicotine withdrawal sensitivity

    NamePosition*Genomic†MAF‡ChisqGlobal PFDR Q
    rs1799971154452910Ex1-1730.133.280.07020.0821
    rs477292154455500IVS1+24180.2265.730.01670.0586
    rs4870266154461111IVS1+80290.0660.0180.89370.5534
    rs610231154470590IVS1+175080.1132.190.13900.1463
    rs3823010154471265IVS1+181830.1784.140.04180.0599
    rs589046154485251IVS1-178230.2615.900.01520.0586
    rs563649154500080IVS1-29940.0850.390.53160.5082
    rs9322446154500815IVS1-22590.1364.790.02860.0599
    rs510587154505541IVS3+7110.0544.000.04550.0599
    rs9282821154506488IVS3-300.4130.130.71730.5188
    rs3798683154510527IVS4+37590.1944.290.03840.0599
    rs599548154510674IVS4+39060.133<0.010.95620.5592
    rs623956154522138IVS4-97920.2380.240.62760.5082
    rs606148154528099IVS4-38310.0994.290.03830.0599
    rs1323041154531293IVS4-6370.4630.070.78860.5188
    rs512053154531629IVS4-3010.080.090.76790.5188
    rs10485058154537327IVS5+49080.1215.770.01640.0586
    rs613355154541962IVS5+95430.3470.240.62340.5082
    • ↵*Chromosome positions are based on NCBI Human Genome Assembly, chr6.

    • ↵†Genomic annotation obtained at genewindow.nci.nih.gov.

    • ↵‡Minor allele frequency of the SNP in the SMOFAM sample.

Additional Files

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    • Supplementary Table 1
    • Supplementary Table 2
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Cancer Epidemiology Biomarkers & Prevention: 18 (12)
December 2009
Volume 18, Issue 12
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Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) Sample
Jill Hardin, Yungang He, Harold S. Javitz, Jennifer Wessel, Ruth E. Krasnow, Elizabeth Tildesley, Hyman Hops, Gary E. Swan and Andrew W. Bergen
Cancer Epidemiol Biomarkers Prev December 1 2009 (18) (12) 3399-3406; DOI: 10.1158/1055-9965.EPI-09-0960

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Nicotine Withdrawal Sensitivity, Linkage to chr6q26, and Association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) Sample
Jill Hardin, Yungang He, Harold S. Javitz, Jennifer Wessel, Ruth E. Krasnow, Elizabeth Tildesley, Hyman Hops, Gary E. Swan and Andrew W. Bergen
Cancer Epidemiol Biomarkers Prev December 1 2009 (18) (12) 3399-3406; DOI: 10.1158/1055-9965.EPI-09-0960
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