Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Collections
      • Highly Cited Collection
      • Prevention and Early Detection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Collections
      • Highly Cited Collection
      • Prevention and Early Detection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
Research Articles

Physical Activity and Survival after Diagnosis of Invasive Breast Cancer

Crystal N. Holick, Polly A. Newcomb, Amy Trentham-Dietz, Linda Titus-Ernstoff, Andrew J. Bersch, Meir J. Stampfer, John A. Baron, Kathleen M. Egan and Walter C. Willett
Crystal N. Holick
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Polly A. Newcomb
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amy Trentham-Dietz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Linda Titus-Ernstoff
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew J. Bersch
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Meir J. Stampfer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John A. Baron
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kathleen M. Egan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Walter C. Willett
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1055-9965.EPI-07-0771 Published February 2008
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Previous studies suggest that increased physical activity may lower the risk of breast cancer incidence, but less is known about whether levels of physical activity after breast cancer diagnosis can influence survival. We prospectively examined the relation between postdiagnosis recreational physical activity and risk of breast cancer death in women who had a previous invasive breast cancer diagnosed between 1988 and 2001 (at ages 20-79 years). All women completed a questionnaire on recent postdiagnosis physical activity and other lifestyle factors. Among 4,482 women without history of recurrence at the time of completing the questionnaire, 109 died from breast cancer within 6 years of enrollment. Physical activity was expressed as metabolic equivalent task-hours per week (MET-h/wk); hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards regression. After adjusting for age at diagnosis, stage of disease, state of residence, interval between diagnosis and physical activity assessment, body mass index, menopausal status, hormone therapy use, energy intake, education, family history of breast cancer, and treatment modality compared with women expending <2.8 MET-h/wk in physical activity, women who engaged in greater levels of activity had a significantly lower risk of dying from breast cancer (HR, 0.65; 95% CI, 0.39-1.08 for 2.8-7.9 MET-h/wk; HR, 0.59; 95% CI, 0.35-1.01 for 8.0-20.9 MET-h/wk; and HR, 0.51; 95% CI, 0.29-0.89 for ≥21.0 MET-h/wk; P for trend = 0.05). Results were similar for overall survival (HR, 0.44; 95% CI, 0.32-0.60 for ≥21.0 versus <2.8 MET-h/wk; P for trend <0.001) and were similar regardless of a woman’s age, stage of disease, and body mass index. This study provides support for reduced overall mortality and mortality from breast cancer among women who engage in physical activity after breast cancer diagnosis. (Cancer Epidemiol Biomarkers Prev 2008;17(2):379–86)

  • physical activity
  • survival
  • breast cancer
  • prospective study
  • epidemiology

Footnotes

  • Grant support: The Susan G. Komen Breast Cancer Foundation grant POP0504234 and National Cancer Institute, NIH, Department of Health and Human Services grants CA47147, CA47305, CA69664, and CA94880.

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted November 19, 2007.
    • Received August 22, 2007.
    • Revision received November 6, 2007.
View Full Text
PreviousNext
Back to top
Cancer Epidemiology Biomarkers & Prevention: 17 (2)
February 2008
Volume 17, Issue 2
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Physical Activity and Survival after Diagnosis of Invasive Breast Cancer
(Your Name) has forwarded a page to you from Cancer Epidemiology, Biomarkers & Prevention
(Your Name) thought you would be interested in this article in Cancer Epidemiology, Biomarkers & Prevention.
Citation Tools
Physical Activity and Survival after Diagnosis of Invasive Breast Cancer
Crystal N. Holick, Polly A. Newcomb, Amy Trentham-Dietz, Linda Titus-Ernstoff, Andrew J. Bersch, Meir J. Stampfer, John A. Baron, Kathleen M. Egan and Walter C. Willett
Cancer Epidemiol Biomarkers Prev February 1 2008 (17) (2) 379-386; DOI: 10.1158/1055-9965.EPI-07-0771

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Physical Activity and Survival after Diagnosis of Invasive Breast Cancer
Crystal N. Holick, Polly A. Newcomb, Amy Trentham-Dietz, Linda Titus-Ernstoff, Andrew J. Bersch, Meir J. Stampfer, John A. Baron, Kathleen M. Egan and Walter C. Willett
Cancer Epidemiol Biomarkers Prev February 1 2008 (17) (2) 379-386; DOI: 10.1158/1055-9965.EPI-07-0771
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Particulate Matter, Ozone, and Cancer Risk
  • Metrics Evaluating Impact of Continued Research
  • Decision Support and Navigation for CRC Screening in Hispanics
Show more Research Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Epidemiology, Biomarkers & Prevention

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2019 by the American Association for Cancer Research.

Cancer Epidemiology, Biomarkers & Prevention
eISSN: 1538-7755
ISSN: 1055-9965

Advertisement